原创力文档the role of macrophage migration inhibitory factor (mif) in ultraviolet radiation-induced carcinogenesis巨噬细胞移动抑制因子(mif)的角色在紫外线辐射致癌作用.pdfVIP
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the role of macrophage migration inhibitory factor (mif) in ultraviolet radiation-induced carcinogenesis巨噬细胞移动抑制因子(mif)的角色在紫外线辐射致癌作用
Cancers 2010, 2, 1555-1564; doi:10.3390/cancers2031555
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
The Role of Macrophage Migration Inhibitory Factor (MIF) in
Ultraviolet Radiation-Induced Carcinogenesis
Tadamichi Shimizu
Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of
Toyama, Sugitani, 930-0194, Toyama, Japan; E-Mail: shimizut@med.u-toyama.ac.jp;
Tel.: +81-76-434-7305; Fax: +81-76-434-5028
Received: 23 June 2010; in revised form: 5 August 2010 / Accepted: 6 August 2010 /
Published: 9 August 2010
Abstract: Ultraviolet (UV) radiation is the most common cause of physical injury to the
skin due to environmental damage, and UV exposure substantially increases the risk of
actinic damage to the skin. The inflammatory changes induced by acute UV exposure
include erythema (sunburn) of the skin, while chronic exposure to solar UV radiation causes
photo-aging, immunosuppression, and ultimately, carcinogenesis of the skin. After skin
damage by UV radiation, the cells are known to secrete many cytokines, including
interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-α. and macrophage migration
inhibitory factor (MIF). MIF was originally identified as a lymphokine that concentrates
macrophages at inflammatory loci, and is known to be a potent activator of macrophages
in vivo. MIF is considered to play an important role in cell-mediated immunity. Since the
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