原创力文档the structure of ca2+ sensor case16 reveals the mechanism of reaction to low ca2+ concentrationsca2 +传感器case16的结构揭示了反应机理ca2 +的浓度较低.pdfVIP
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thestructureofca2sensorcase16revealsthemechanismofreactiontolowca2concentrationsca2传感器case16的结构揭示了反应机理ca2的浓度较低
Sensors 2010, 10, 8143-8160; doi:10.3390/s100908143
OPEN ACCESS
sensors
ISSN 1424-8220
/journal/sensors
Article
The Structure of Ca2+ Sensor Case16 Reveals the Mechanism of
Reaction to Low Ca2+ Concentrations
Lukas Leder #,1, Wilhelm Stark #,1,2, Felix Freuler 1, May Marsh 1, Marco Meyerhofer 1,
Thomas Stettler 1, Lorenz M. Mayr 1,3, Olga V. Britanova 4, Lydia A. Strukova 4,
Dmitriy M. Chudakov 4 and Ekaterina A. Souslova 4,*
1 Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland;
E-Mails: lukas.leder@ (L.L.); wilhelm.stark@intergga.ch (W.S.);
felix.freuler@ (F.F.); may.marsh@ (M.M.);
marco.meyerhofer@ (M.M.); thomas.stettler@ (T.S.);
lorenz.mayr@ (L.M.M.)
2 Fachhochschule Nordwestschweiz, Institute for Chemistry and Bioanalytics. Gruendenstrasse 40,
CH-4132 Muttenz, Switzerland
3 Novartis Pharma AG, NIBR/CPC/EPP, Lichtstrasse 35, CH-4002 Basel, Switzerland
4 Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10,
117997, Moscow, Russia; E-Mails: Britanova@em.mpg.de (O.V.B.) lidda@list.ru (L.A.S.);
chudakovdm@mail.ru (D.M.C.)
* Author to whom correspondence should be addressed; E-Mail: souslova@;
Tel: +7-495-429-8020; Fax: +7-495-330-7056.
# Authors who contributed equally.
Received: 25 June 2010; in revised form: 28 July 2010 / Accepted: 12 August 2010 /
Published: 30 August 2010
Abstract: Here we report the first crystal structure of a high-contrast genetically encoded
circularly permuted green fluorescent protein (cpGFP)-based Ca2+ sensor, Case16, in the
presence of a low
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