the thymus is a common target organ in infectious diseases胸腺是一种常见的传染性疾病的靶器官.pdfVIP

Review The Thymus Is a Common Target Organ in Infectious Diseases Wilson Savino ABSTRACT of these intrathymic cellular compartments, comprising proliferation, death, secretion, migration, and nfectious disease immunology has largely focused on the differentiation. Selected examples of viral and parasitic I effector immune response, changes in the blood and infectious diseases will be discussed in more detail. peripheral lymphoid organs of infected individuals, and Nevertheless, before compiling and discussing these data, it is vaccine development. Studies of the thymus in infected worthwhile to provide a general background on the structure individuals have been neglected, although this is progressively of the thymic microenvironment and its role in intrathymic T changing. The thymus is a primary lymphoid organ, able to cell differentiation. generate mature T cells that eventually colonize secondary The thymic microenvironment and T cell differentiation. lymphoid organs, and is therefore essential for peripheral T The thymus is a primary lymphoid organ in which bone cell renewal. Recent data show that normal thymocyte marrow-derived T cell precursors undergo differentiation, development and export can be altered as a result of an ultimately leading to migration of positively selected infectious disease. One common feature is the severe atrophy thymocytes to the T cell-dependent areas of peripheral of the infected organ, mainly due to the apoptosis-related lymphoid organs. This process involves sequential expression depletion of immature CD4þCD8þ thymocytes. Ad