原创力文档the thyroid function of graves disease patients is aggravated by depressive personality during antithyroid drug treatment甲状腺机能亢进患者的甲状腺功能是抗甲状腺药物治疗期间加重抑郁人格.pdfVIP
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the thyroid function of graves disease patients is aggravated by depressive personality during antithyroid drug treatment甲状腺机能亢进患者的甲状腺功能是抗甲状腺药物治疗期间加重抑郁人格
Fukao et al. BioPsychoSocial Medicine 2011, 5:9
/content/5/1/9
RESEARCH Open Access
The thyroid function of Graves’ disease patients is
aggravated by depressive personality during
antithyroid drug treatment
1* 2 3 3 4
Atsushi Fukao , Junta Takamatsu , Sumihisa Kubota , Akira Miyauchi and Toshiaki Hanafusa
Abstract
Background: We previously reported that depressive personality (the scores of hypochondriasis, depression and
psychasthenia determined by the Minnesota Multiphasic Personality Inventory (MMPI)) and daily hassles of Graves’
disease (GD) patients treated long trem with antithyroid drug (ATD) were significantly higher in a relapsed group than
in a remitted group, even in the euthyroid state. The present study aims to examine the relationship among depressive
personality, emotional stresses, thyroid function and the prognosis of hyperthyroidism in newly diagnosed GD patients.
Methods: Sixty-four untreated GD patients responded to the MMPI for personality traits, the Natsume’s Stress
Inventory for major life events, and the Hayashi’s Daily Life Stress Inventory for daily life stresses before and during
ATD treatment.
Results: In the untreated thyrotoxic state, depressive personality (T-scores of hypochondriasis, depression or
psychasthenia greater than 60 points in MMPI) were found for 44 patients (69%). For 15 (23%) of these patients,
the scores decreased to the normal range after treatment. However, depressive personality persisted after
treatment in the remaining 29 patients (46%). Normal scores before treatment were found for 20 patients (31%),
and the scores were persistently normal for 15 patients (23%). The remaining 5 patients (8%) had higher depressive
personality after
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