氟伐他汀对自发性高血压大鼠阻力血管功能的影响-Acta.PDF

IS．qN02N~-9756 AclaFharmacolsm中国药理学报 1999Sep；20(9)：85-5—8∞ http：．／／www simm acC3l； www chinainfo govc~．／ixnodical Effectsoffluvastatinon structureandfunction of resistantvesselsin spontaneouslyhypertensiverats LIN -Hong，XIE Liang．Dit WUKe—Gui，WANGHua—Jun，XU Chang—Sheng ， (HypertensionDivision，F AffiliatedHo~ital，FufianMedicalUniversity，Fuz~hou350005．China) KEY WORDS fluvastatin；hydmxymethylglutatyl— Short-term treatmentwiht fluvastatin amelioratde 山e CoA reductase inhibitors； inbred SHR rats； vasomotoricity of resistant vessels， enhanced hte thoracicaorta mesenteric arteries； v~ liLafion； sensitivitytovasodilatoranddepressedthesensitiviyt to hypertension vasoconstrictor；fluvastafinalsoattenuatedhteresistant vascular hypertrophy during hte development of hypertnesioninSHR． 删 ： To evaluate the effects of fluvastatin， a hydroxymehtylglutaty1-CoA (HMG-CoA ) reductase inhibitor．onhtealterafionsofStrUCtUreandfunctionof As a potent inhibitot of3．hvdroxy一3．mehtyl— resistant vessels ni spontaneously hypertensive rats gluyrarylcoenzymeA (HMG·CoAjreductase(hterate (SHR) M哐T】DDS：Eight-week—old maleSHR limitingenzymenicholesterolbiosynhtesis)，fluvastatni were given fluvastatin 20 mg k‘g d‘ by gavage． veaseffective in notonly reducing serum lipids，but Ratswere decapitatedat16 wk． Wall—t-ohin~n raea also inhibiting cultured vascularsmooht muscle cells ratios(W ／L)ofhtoracicnar／：anadmesentericarteries (VSMC)proliferationnadmigrationlij． Itexhibited (3rdgradebranch)were assessde by lT1ornh0rne c hte ability to reverse endohtelial dvsfunction nad to assay． Theeffects offluvastatinonvascularreactivity prevent restenosis after successful percutaneous