抗血管生成药物致高血压的降压治疗的合理用药.pdfVIP

第 卷 第 期 临床药物治疗杂志 15 1 Vol.15,No.1 2017 年 1 月 Clinical Medication Journal Jan,2017 宇文利霞, 等:抗血管生成药物所致高血压的合理用药 抗血管生成药物致高血压的降压治疗的合理用药 宇文利霞 , 时绘绘 , 孙鑫晔 , 袁耀辉 （邢台市第三医院药剂科，河北邢台 054000） 【摘要】高血压是抗血管生成药物常见不良反应之一，多为轻、中度。一般通过标准降压治疗即可控制，而严重 者可影响患者的抗肿瘤疗效果甚至中断靶向药物治疗。因此，合理选择降压药物对于患者的抗肿瘤治疗具有重要意义。 笔者主要探讨抗血管生成药物致高血压的降压药物选择 ，以期为临床用药提供参考。 【关键词】抗血管生成药物；高血压；血管紧张素转换酶抑制剂 ；血管紧张素受体拮抗剂 【中图分类号】R726.14 【文献标志码】A 【文章编号】1672-3384(2017)01-0059-03 doi:10.3969/j.issn.1672-3384.2017.01.012 Rational medication of hypertension induced by anti-angiogenesis drugs YUWEN Li-xia, SHI Hui-hui, SUN Xin-ye, YUAN Yao-hui （Department of Pharmacy, No.3 Hospital of Xingtai, Hebei Xingtai 054000, China ） Abstract Hypertension is a common toxicity of anti-angiogenesis drugs, and mostly expresses as mild or moderate. Generally, 【 】 it can be controlled by standard antihypertensive treatment. However, the anti-tumor effect of anti-tumor drugs can be affected or even interrupt therapy because of severe hypertension. Therefore, reasonable selection of antihypertensive drugs is of great significance for the treatment of tumor patients. This paper mainly discusses the rational use of drugs in the treatment of hypertension induced by anti- angiogenesis drugs, in order to provide reference for clinical medication. Key words anti-angiogenesis drugs; hypertension; angiotensin-converting enzyme inhibitor; angiotensin receptor blocke