模拟微重力对肺淋巴细胞功能影响及作用机制.pdf

兰鳘建堡兰夔篷主兰堡垒奎———～—— of mechanism and offunctional Investigation change asimulated T in under lung lymphocytes condition microgravity Abstract wasconductedto the Objective：Thepresentstudy investigate T undera simulated fimctional of microgravity changesIymphocytes ofthese T anddelineatethemechanism condition changes。Weinvestigated undersimulated andstudiedthe cells’dysfunctions microgravity PKC—mediated and ERK pmhwayRas·dependentsignaling signaling two eventsinactivationofTcells。Wealsostudiedthe key pathway，the functionalroleof asamodulatorof andthemechanism leptin lymphocyte the underthesimulated behindthe of two change signalingpathways microgravity． this T wereisolatedfromrats．In Methods：1．Lunglymphocytes CellCulture at developed Rotary System(RCCS)technology regard，the NASA tocreatethe