黄芩苷对实验性大鼠肺纤维化影响及机制初探.pdfVIP

中文摘要 四结论 1．连续给予黄芩苷(100 mg·kg。1·d～X28d，ip)有 加重BLM．A5诱导大鼠肺纤维化的作用，此作用可能与其通 过加重肺损伤、上调TGF．pl的表达有关。 2．连续给予黄芩苷(100 mg·k重1-d～X28 d，ip)使 肺泡巨噬细胞中泡沫细胞百分率的降低与其加重大鼠肺纤 维化的关系还有待于进一步研究。 关键词：黄芩苷；肺纤维化；博莱霉素；转化生长因子 一Bl；免疫组织化学；泡沫细胞；大鼠 英文摘要 on ofBaicalin Effects pulmonary experimental itsmechanisms fibrosisofratsand ABSTRACT Aim 1 and Bael‘ground thatis disease isaninterstitial fibrosis lung Pulmonary ofalveolar cell characteristic absence，fibrocyte epithelial matrix andthedisorder apposition proliferation，extracellular mechanismsof fibrosishave of structure．The pulmonary lung not beenwellclarified．At isknownthat yet present，it ofthe one 1)is 1(TGF一13 growthfactor-13 transforming that fibrosis．Foam cytokinespromotepulmonary important cellis derivedfrom after macrophagephagocytizing foundin