普鲁卡因静脉封闭治疗顽固瘙痒症的疗效观察.pdfVIP

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普鲁卡因静脉封闭治疗顽固瘙痒症的疗效观察.pdf

普鲁卡因静脉封闭治疗顽固瘙痒症的疗效观察 吴定苏 ,林乐泓,詹美伶 ,练思玉,李晓英(1.东莞市莞城人民医院皮肤科,广东东莞 523900;2.东莞市 莞城人民医院外科,广东东莞 523900;3.东莞市莞城人民医院功能科,广东东莞 523900) 中图分类号 R986 文献标志码 A 文章编号 1672—2124(2015)06—0740—03 DOI 10.14009/j.issn.1672—2124.2015.06.014 摘 要 目的:探讨普鲁卡因静脉封闭治疗顽固瘙痒症的临床效果。方法:将 168例顽固性皮肤瘙痒症患者按照随机数字抽签方 法分为2组,对照组患者给予常规治疗,观察组患者在此基础上加用普鲁卡因静脉封闭治疗,对比2组患者的治疗效果。结果:观 察组患者临床症状改善时间显著短于对照组,差异有统计学意义(P0.01);2组患者总有效率的差异无统计学意义(P0.05), 但观察组患者显效率显著大于对照组(P0.05)。治疗期间2组患者均未见明显不良反应。结论:在常规治疗的基础上应用普 鲁卡因静脉封闭治疗顽固瘙痒症,能从瘙痒的产生和传递环节同时给予干预,从而达到更好的治疗效果,对于改善患者病情具有 积极意义。 关键词 顽固瘙痒症;普鲁卡因;马来酸氯苯那敏 EfficacyofIntravenousProcaineBlockTherapyforIntractablePruritus WU Dingsu ,LIN Lehong ,ZHAN Meiling。 , LIANSiyu,LIXiaoying(1.Dept.ofDermatology, DongguanGuanchengPeople’SHospital,GuangdongDongguan 523900,China;2.Dept.ofSurgery, DongguanGuanchengPeople’SHospital,GuangdongDongguan523900,China;3.Dept.ofFunction, DongguanGuanehengPeople’SHospital,GuangdongDongguan523900,China) ABSTRACT OBJECTIVE:Toevaluatetheclinicalefficacyofintravenousprocaineblock therapyforintractable pruritus.METHODS:168patientswith intractableprurituspatientswererandomlydivided intotwogroups,withthe patientsinthecontrolgroupreceivedconventionaltherapyal0ne.whilethepatientsintheobservationrgoupweretreated withadd—onintravenousprocaineblocktherapy,withtherapeuticefficacycomparedbetweenthetworgoups.RESULTS: Theobservationgroupshowed significantlyearlierimprovementinclinicalsymptomsthanin thecontrolgroup and the differencewasstatisticallysignificant(P0.01);thedifferencesinthetotaleffectiveratebetweenthetwogroupswere ofnostatisticalsignificance(P 0.05);however,themarkedlyeffectiveratewassignificantlyhigherintheobservation groupthaninthecontrolgroup(P0.05).Duringthetreatment,significantadversereactionswerenotedinnoneofthe patientsinthe2rgoups.CONCLUSIONS:Additionofintravenousprocaineblocktherapytotheconventionaltherapy resultedinbettertherapeuticefficacyinthetreatmentofintractablepruritus

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