新加良附方对移植性人胃癌抑制效应研究.pdfVIP

· 14 · 北京中医药大学学报(中医临床版) 2008年 1月，l5(1) · 血液与肿瘤论坛· 新加良附方对移植性人胃癌抑制效应研究 董青 李春 马成杰 陈信义1,3 (1北京中医药大学东直门医院肿瘤血液科 北京100700：2中国医学科学院肿瘤 研究所；3北京中医药大学东直门医院中医内科学教育部重点实验室，北京市重点实验室) 摘要：目的观察新加良附方对移植性人胃癌抑制效应。方法人源胃癌细胞系(BGC一823)经传代培养后。通过BALB／C—BU裸鼠 移植制造肿瘤模型，以5一氟尿嘧啶和不同剂量的新加良附方浸膏进行干预性治疗，用抑瘤率评价新加良附方对BGC一823移植 瘤生长的抑制作用。结果5一氟尿嘧啶组及新加良附方大、中、小剂量组的肿瘤抑制率分别为54．2％、54_3％、36．8％和23_3％： 5一氟尿嘧啶组及新加良附方大剂量组与模型组瘤重比较，有统计学意义(PO．05)。结论 新加良附方大剂量组对BGC一823有明 显抑制作用。 关键词：新加良附方：人胃癌细胞系；肿瘤抑制率 中图分类号：R273 Inhibitory effect of Xinjialiangfu Formula on transplantation human gastric cancer DONG Qing。，LI Chun ，MA Cheng-jie ，CHEN Xin—yi (1 Department of Oncology and Heamatology，Dongzhimen Hospital， Beijing University of Chinese Medicine，Beijing 100700；2 Oncology Institute，Chinese Academy of Medical Sciences；3 Key Laboratory of Chinese Internal Medicine of Bering and Educational Ministry，Dongzhimen Hospital，Bering University of Chinese Medicine) Abstract：Objective To observe the inhibitory effect of Xi~iMiangfu Formula on transplantation human gastric cancer． Methods After culturing and propagating BGC一823 of human gastric cancer was implanted to BALB／C—BU mice to establish the tumor model， which then was treated interferingly with 5-fluorouracil(5-FU)and different doses of Xinjialiangfu Formula．The inhibitory effect of Xinjialiangfu Formula on BGC——823 was evaluated by the tumor inhibitory rate． Results The tumor inhibitory rates of 5-FU group and different-dose Xinjialiangfu Formula groups weie respectively 54．2％．54．3％．36．8％and 23．3％．The comparison between the model group and 5-FU group or high-dose Xinjialiangfu Formula group in tumor weight was significant statistically (P0．05)． Condusion High-dose of Xinjialiangfu Formula has a significant inhibitory effect on BGC-823 of human gastric cancer． Key words：Xi~iabangfu Formula；cell line of human gastric cancer；tumor inhibitory rate 董青．女，在读博士生 阴虚故目不瞑。”抑郁障碍相关性失眠作为一种症 郁障碍相