《Syndromes of Resistance to Thyroid Hormone Action -Brent》经典培训课件.pptVIP

TRb TRbK50Q TRbKI46Q TRbK443Q A. TRb Sumoylation Site Mutants Inhibit 3T3L1 Preadipocyte Differentiation  Liu et al J Biol Chem 290:7402, 2015 TR Sumoylation Summary Liu et al J Biol Chem 290:7402, 2015 Mutant interfering with PPARg-mediated transcription of Plin1, aP2 and adipoQ. TRa sumoylation site mutant, K283Q/288R, reduces nuclear cyclin D1-Cdk4 complex in G1 phase, in human preadipocytes Thyroid Hormone Receptors and Proliferation/Differentiation Cell type Pro-liferation Main recep-tor Genes/pathways involved Modulated biological response Hepatocyte TRb Cyclin D1 Liver hyperplasi