《Zimmermann lecture Merck Thyroid Meeting April 2017》经典培训课件.pptxVIP

Iodine intake and thyroid cancer;;;;The question:Over past 3-4 decades, in many countries, there have been increases in iodine intake and, at the same time, increases in incidence of papillary thyroid cancerare these causally related?;Suspected risk factors for thyroid cancer include: ;Iodine intake and thyroid cancer: is there a link?;Proposed mechanisms linking iodine intake and thyroid cancer;Sufficient/excess thyroidal iodide: iodide oxidized and HIF‐1α unstable, unable to bind VEGF promoter, reducing VEGF expression Deficient iodide: cytoplasmic ROS high because no iodide to be oxi