哺乳动物中丙酮酸脱氢酶复合体的活性调节-生物技术通报.pdfVIP

生物技术通报 # # BI OTECHN OLOG Y B ULLETI N 2006 1 李凤艳 刘晓晴 ( , 100037) : 高等生物的一个重要代谢调控机制是通过对酶的磷酸化和去磷酸化 进行的, 哺乳动物的丙酮酸 脱氢酶复合体( pyr uv ate dehydro genase co mplex, PDH c) 也是如此PDH c 的活性的调节主要是通过对其E 1( pyru- v ate dehydro genase, PDH ) 的磷酸化和去磷酸化 实现的当机体主要靠储存的脂肪生存而所存的葡萄糖仅供大 脑和神经组织等只能依靠葡萄糖 提供能量的器官使用的时候, 即葡萄糖缺乏时, 就需要抑制P DH c 的活性主 要探讨了哺乳动物在特定器官中和特定的一些生理条件下, PDH c 活性改变的一些规律 : 丙酮酸脱氢酶复合体 丙酮酸脱氢酶激酶 活性调节 磷酸化 去磷酸化 Regulation of the Activity of the Mammalian Pyruvate Dehydrogenase Complex L Fengyan l u X ao q ng ( Col le ge of L if e S ci ence , Cap it al N ormal Univ ers i ty , B eij in g 100037) Abstract: T hr ough the pho sphor ylat on and depho sphor ylat o n of the E 1( py ruvate dehy dr og enase, PDH ) o f the P DH c, the act v ty of the M ammal an py ruvate dehy dr og enase complex has been r egu- lated . W hen the bo dy should be l v ng pr mar ly o ff ts sto red f at and ther eby co nserv e ng gluco se for u se by the br a n , the r at e of pyr uv ate decarbox ylat o n has to be carefully contr- olled to match the o vera ll energ y need o f the bo dy . In th s paper, M echa- n sm s have there- for e d scu ssed to nact v ate the py ruvate dehy dr og enase complex w hen gluco se becomes scar ce. Key w ords: Py ruvate dehy dr og enase complex Pyr uvate dehy dr og enase k nase Reg ulat on of the act v ty Phospho ry lat on Dephosphor ylat on , PDH c , ( ) ( , ) , PD K P DP PDH c acet yl- Co A , NA D+ , PD K PDP NA DH , , , ( E 1) ( E2) , PDH c ( E3) 1 ( PD K) ( PDP) E3 ( E3BP ) , PD