间充质干细胞诱导分化为肺泡上皮细胞治疗急性呼吸窘迫综合征研究.pdfVIP

( ) 2017 4 7 2 Chin J Cell Stem Cell (Electronic Edition), Apr 2017,Vol.7, No.2 124 中华细胞与干细胞杂志 电子版 年 月第 卷第 期 · · ·综述· 间充质干细胞诱导分化为肺泡上皮细胞 治疗急性呼吸窘迫综合征研究进展 陈钦桂 曾勉 【摘要】 以高死亡率著称的急性呼吸窘迫综合征（ARDS）是呼吸与重症医学领域亟需攻 克的难题之一。来源广泛、体外易扩增培养的间充质干细胞（MSC ）有望为ARDS 的治疗提供 新的有效手段。已有较多的相关研究显示了MSC 治疗ARDS 的有效性，而通过分化为肺泡上 皮细胞修复损伤肺组织可能是其治疗机制之一。本文对MSC 诱导分化为肺泡上皮细胞及其应 用于治疗ARDS 的研究进展进行综述，以期为该领域相关工作者提供一定的借鉴与启示。 【关键词】 间质干细胞； 肺泡； 上皮细胞； 急性病； 呼吸窘迫综合征 Advances in research of induced differentiation of mesenchymal stem cells into alveolar epithelial cells for treatment of ARDS Chen Qingui, Zeng Mian. Medical Intensive Care Unit, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Corresponding author: Zeng Mian, Email: zengmian2004@163.com Abstract 【 】 Acute respiratory distress syndrome （ARDS ）, which is notorious for its high mortality rate, is one of the greatest challenges in the field of respiratory and critical care medicine. Mesenchymal stem cell （MSC ）, which is readily available and easily expandable in vitro, is considered to be a promising therapy for ARDS. Numerous studies have shown the effectiveness of MSC in the treatment of ARDS. Although the mechanism is not completely understood, differentiation of MSC into alveolar epithelial cells to repair inj ured lung tissue may be one of the possible mechanisms. Herein, research progress of induced differentiation of MSC into alveolar epithelial cells and its application in the treatment of ARDS is reviewed. Key words 【 】 Mesenchymal stem cells; Pulmonary alveoli; Epithelial cells; Acute disease; Respiratory distress syndrome [5] 急 性 呼 吸 窘 迫 综 合 征（acute respiratory di