原人参二醇及compoundk抑制肝细胞肝癌的作用及机制.pdfVIP

Traditional Chinese Medicine 中医学, 2017, 6(2), 104-109 Published Online May 2017 in Hans. /journal/tcm /10.12677/tcm.2017.62018 The Inhibitory Effect of Protopanoxadiol and Compound K on Hepatocellular Carcinoma and the Underlying Mechanisms 1 1 2 1* Chunlei Zhang , Haiyan Song , Yangxian Xu , Guang Ji 1 Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 2 Department of General Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai th rd th Received: May 8 , 2017; accepted: May 23 , 2017; published: May 26 , 2017 Abstract There is still no effective treatment available for advanced liver cancer or the recurrence and me- tastasis after surgical resection. Protopanoxadiol (PPD) and ginsenoside Compound K are the me- tabolites of protopanaxadiol-type ginsenosides in vivo. In recent years, a number of studies have found that these two kinds of natural products could play a role of tumor suppression through in- ducing cell apoptosis, inhibiting cell proliferation, inhibiting angiogenesis and limiting tumor cell metastasis. Among them, there are many studies focusing on the effect of PPD or Compound K on hepatocellular carcinoma (HCC), in which the anti-cancer effect is prominent. This paper reviews the recent studies on the role of PPD/Compound K in HCC and the related mechanisms, in order to benefit the development of new effective natural medicine to treat HCC. Keywords Hepatocellular Carcinoma, Protopanoxadiol, Compound K 原人参二醇及Compound K抑制肝细胞肝癌的 作用及机制 1 1 2 1* 张春蕾 ，宋海燕，许阳贤，季 光 1上海中医药大学附属龙华医院脾胃病研究所