哺乳动物脂肪细胞的分化及调控-中国细胞生物学学报.pdfVIP

网络出版时间：2015-12-11 15:11:29 网络出版地址：/kcms/detail/31.2035.Q1511.004.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(12): DOI: 10.11844/cj cb.2015.12.0250 哺乳动物脂肪细胞的分化及调控 高 洋 魏著英 白春玲 李光鹏* ( 内蒙古大学国家动物转基因技术研究中心, 呼和浩特010010) 摘要 从形态特征上, 可以将组成动物机体的脂肪分为白色脂肪、棕色脂肪和米色脂肪。骨 髓来源和脂肪来源的间充质干细胞经血液循环等途径进入各组织器官, 经过增殖形成脂肪祖细胞, 再由祖细胞分化成为脂肪前体细胞与成熟的脂肪细胞。在生理条件下, 白色脂肪与棕色脂肪可以 相互转换, 二者可动态转换。如果二者之间的平衡被打破, 可能会引发多种疾病(如肥胖症、2型糖 尿病、高血脂、脂肪肝、心血管疾病以及乳腺癌等) 。米色脂肪是白色脂肪向棕色脂肪转化时出 现的中间类型。不同类型脂肪之间的转换受若干种因子和因素的调控, 该文将对脂肪的分化及其 调节机制作一综述。 关键词 白色脂肪; 棕色脂肪; 米色脂肪; 脂肪祖细胞; 脂肪前体细胞; 转录调控 Progress in the Regulation of Adipocyte Differentiation Gao Yang, Wei Zhuying, Bai Chunling, Li Guangpeng* (National Center for Animal Transgenic Biotechnology of Inner Mongolia University, Hohhot 010010, China) Abstract On the morphology, animal fat can be divided into white fat, brown fat and beige fat. Marrow- derived and adipose-derived mesenchymal stem cells flowed into all kinds of tissues and organs through blood circulation, after formed adipose progenitor by cell proliferation, and differentiate into fat cells and mature fat cells. Under physiological conditions, white fat and brown fat can be converted each other, they are dynamic conversion process. If the balance between the two adipose is broken, a variety of diseases would be caused, such as obesity, type II diabetes, high blood lipids, fatty liver, cardiovascular disease and breast cancer. Beige fat is an intermediate in the process of white and brown fat conversion. Conversion between different types of fats is