肠道免疫系统与糖尿病关系的研究进展.pdfVIP

中国病理生理杂志 ChineseJournalofPathophysiology 2016，32(11)：2095—2100 杂志网址：http：／／www．cjpp．net [文章编号] 1000-4718(2016)11—2095—06 · 综 述 · 肠道免疫系统与糖尿病关系的研究进展术 巩 静， 董 慧， 王定坤， 方 珂， 胡美霖， 陆付耳 (华中科技大学同济医学院附属同济医院中西医结合研究所 ，湖北 武汉430030) Research progressofintestinalimmunesystem and diabetesmeUitus GONGJing，DONGHui，WANGDing—kun，FANGKe，HU Mei—lin，LUFu—er (InstituteofIntegratedTraditionalChineseandWesternMedicine，TongjiHospital，TongfiMedicalCollege， HuazhongUniversityofScienceandTechnology，Wuhan430030，China．E—mail：felu@珈．咖 edu．ca) [ABSTRACT] Theintestinalimmunesystemplaysanimportantroleinthepathogenesisofdiabetesmellitus．The transplantationofmesentericlymphocytescantransmitdiabetes，whichindicatestheislet-damagingTcellsmaybederived from theintestine．Intestinalvirusinfection，oralglutenantigenandintestinalflorachangesareassociatedwithdiabetes． TheimmunecellsingutincludingTcells，macrophage，naturalkillerceils，dendriticcellsandSOonarealsoconfirmedto beinvolvedinthepathogenesisofdiabetes．Inaddition，intestinalimmunesystem influencestheoccurrenceanddevelopment ofdibaetesbymodulatingtheintestinalbarrierpemr eability，theexpressionofpatternrecognitionreceptors，thechangesof incretinandthedamageofimmunetolerance．Theinductionofgutimmunetoleranceandregulationofintestinal floraforthe treatmentofdiabeteshavealsobeenwidespreadconcerned．Thisarticlesummarizestheresearchprogressontherelationof diabetesandintestinalimmunesystem，andalsobrieflyintroducesthedevelopmentoftheintestineimmunetherapy． [关键词] 肠道免疫系统；糖尿病；免疫细胞；免疫疗法 [KEYWORDS] Intestinalimmunesystem；Diabetesmellitus；Immunecells；Immunetherapy [中图分类号] R363；R587．1 [文献标志码] A doi：10．3969／j．issn．1000—4718．2016．11．031 糖尿病 (diabetesmellitus，DM)发病率呈稳定上 可阻止非肥胖糖尿病小鼠DM的发生 J。此外，饮 升趋势，除基因突变、环境因素外，由于肠道免疫系 食变化可影响BB鼠