血浆b型脑钠肽与老年2型糖尿病患者心脏舒张功能的关系余惠珍1陈.docVIP

血浆B型脑钠肽与老年2型糖尿病患者心脏舒张功能的关系 余惠珍1 陈良1 林宁2 (1福建医科大学省立临床医学院干部特诊二科 福建省临床老年病研究所 福州 350001；2 福建医科大学省立临床医学院彩超室 福州 350001) 通讯作者：余惠珍，yhz200333@126.com cell-phone[基金项目]福建省卫生厅青年基金(2338). 【摘要】：目的：探讨血浆B型脑钠肽(pro-BNP)水平与老年2型糖尿病伴舒张性心功能不全(DHF)的关系及早期诊断的临床意义。方法 选取67例采用超声心动图检测LVEF正常的老年2型DM患者，按二尖瓣舒张早期血流速度／二尖瓣舒张晚期血流速度(E／A)比值分为心功能正常组22例，DHF 1级组18例，DHF 2级组17例，DHF 3级组10例。正常对照组为本院健康体检者l3例。采用电化学发光法2型糖尿病伴心脏舒张功能不全组的B型脑钠肽水平差异具有显著性意义(P0.01)；血浆B型脑钠肽水平随着舒张功能不全程度加重而逐渐提高，与E/A比值呈显著负相关(r=-0.78, P0.01）。结论：血浆B型脑钠肽水平与老年2型糖尿病患者的心脏舒张期功能障碍程度密切相关，可反映老年2型糖尿病患者的心舒张功能状态。 【关键词】 2型糖尿病； 脑钠素；心脏舒张功能不全；老年人 The Clinical Study of N-terminal pro-plasma brain natriuretic peptide in aged patients of type 2 diabetes mellitus with diastolic heart failure Huizhen Yu1 Liang Chen1 Ning Lin2 (1 Second Medical Department，Fujian Provincial Hospital, Provincial Clinical College, Fujian Medical University, Fujian Institute of Clinical Geriatrics, Fuzhou 350001,China；1 2 Department ofUltrasonograph，Fujian Provincial Hospital, Provincial Clinical College, Fujian Medical University, Fuzhou 350001,China.) 【Abstract】Objective To study the relationship and diagnostic value between n-terminal pro-brain natriuretic peptid (pro-BNP)and the severity of diastolic heart failure(DHF)in aged patients of type 2 diabetes mellitusMethods 67 type 2 diabetic mellitus aged patients and 13 healthy subjects served as control were selected into the study.Left ventricular ejection fraction(LVEF) and mitral annular early diastole(E) and late diastole(A) inflow velocities were measured with Doppler echocardiography．According to the ratio of E to A, the severity of DHF patients were subdivided into 3 groups:DHF 1 group(0．8≤ E／A1,n=18),DHF 2 group(0.6≤ E／A0.8, n=17),DHF 3 group(E／A0.6, n=10). The plasma level of pro-BNP was measured by the enzyme-linked immunosorbent assay. Results：Plasma pro-BNP was significantly increased （P〈0.01〉）in type 2 diabetes mellitus with DHF（1538±237.9 pg/ml ）as compered with those without DHF（896.5±168.7 pg/m