1c与血清可溶性细胞间黏附分子—1影响-- 牙周非手术治疗对2型糖尿病伴牙周炎患者糖化血红蛋白A1c与血清可溶性细胞间黏附分子—1影响.docVIP

1c与血清可溶性细胞间黏附分子—1影响’ 牙周非手术治疗对2型糖尿病伴牙周炎患者糖化血红蛋白A1c与血清可溶性细胞间黏附分子—1影响 　　[摘要] 目的 探讨牙周非手术治疗对2型糖尿病伴慢性牙周炎（DMCP）患者牙周状况、糖代谢及血清可溶性细胞间黏附分子-1（sICAM-1）的影响。方法 选择诊断为2型糖尿病伴慢性牙周炎的患者，按糖化血红蛋白A1c（GHbA1c）控制水平分为血糖控制良好组（GHbA1c0.05）。治疗后3个月时，DMCP2组GHbA1c水平与基线时比较平均降低1.12%，差异有统计学意义（P0.05）。结论 牙周非手术治疗可降低2型糖尿病伴牙周炎患者的牙周炎症程度及血清sICAM-1的水平，并可改善血糖控制良好者的牙周附着水平；该治疗还可以降低血糖控制较差者的GHbA1c水平。 [关键词] 慢性牙周炎； 2型糖尿病； 牙周非手术治疗； 糖化血红蛋白A1c； 可溶性细胞间黏附分子-1 [中图分类号] R 781.4 [文献标志码] A [doi] 10.7518/hxkq.2013.04.021 Effect of non-surgical periodontal therapy on level of serum soluble intercellular adhesion molecule-1 and glycated hemoglobin A1c in patients with type 2 diabetes and chronic periodontitis Yuan Tangxia1， Zhang Yan-biao1， Zhou Yun2， Wang Fantao1， Wang Feng3. （1. Dept. of Prosthodontics， School of Stomatology， Weifang Medical College， Weifang 261053， China； 2. Dept. of Stomatology， Chinese Medicine Hospital in Linyi City， Linyi 276000， China； 3. Dept. of Endocrinology， The Affiliated Hospital of Weifang Medical College， Weifang 261031， China） [Abstract] Objective To evaluate the effects of non-surgical periodontal treatment on clinical periodontal measure-ments， glycemic control， and level of serum soluble intercellular adhesion molecule-1（sICAM-1） in type 2 diabetes mellitus with chronic periodontitis patients. Methods Patients with type 2 diabetes and chronic periodontitis were selected and classified into well-controlled group[glycated hemoglobin A1c（GHbA1c） 　　levels of CAL（P0.05）. At 3 months after periodon-tal treatment， GHbA1c levels in DMCP2 group signifi-cantly decreased by 1.12%（P0.05）. Conclusion Non-surgical periodontal treatment can significantly improve periodontal health status in patients with type 2 diabetes and periodontitis， reduce the level of serum sICAM-1， and can reduce the level of GHbA1c in poorly controlled type 2 diabetic patients. [Key words] chronic periodontitis； type 2 diabetes mellitus； non-surgical periodontal therapy； glycated hemo-globin