FAP-1和Fas在子宫内膜癌中的表达及其临床意义.pdf

· 1608 · MODERN ONCOLOGY，Aug．2010，VOI．18，NO．08 FAP一1和Fas在子宫内膜癌中的表达及其临床意义 侯 锐 ，姜 罗 ，曹 薇 ，赵福杰 ExpressionandclinicalsignificanceofFAP一1andFasinendometrialcarcinoma HOuRui，JIANGLuo，CA0Wei，ZHA0Fu—jie 。DepartmentofGynecologyandObstetrics；DepartmentofUltrasound；DepartmentofPathology，ShengfingHospitalofChinaMedicalU- niversity，LiaoningShenyang 110004，China 【Abstract】 Objective：ToinvestigatetheexpressionsofFAP一1andFasaswellastheirrelationshipswithclinical characteristicsinendometrialcracinoma．Methods：Usingimmunohistochemiealtechnique(S—P)，weexaminedthe expressionofFAP一1，Fas in63endometrial carcinomatissues，13endometrialatypicalhyperplasiatissuesand20 normalendometrialtissues．Results：PositiveFAP一1expressionwasobservedin45／63(71．4％)casesofendometri- alcarcinomas，higherthannomralendometrialepithelium(25％，P0．05)．ThepositiverateofFasinendometrial carcinomawaslowerthannomralendometrialepithelium(52．4％ vs85％，P0．05)．ThepositiverateofFAP—1 washigherinFas～negativehtanFas—positivecarcinomacases(93．3％vs51．5％，P0．05)．Thepositiveexpres- sionofFAP一1wascorrelatedwithclinicalstageandhistologygrade(P0．05)，butnotwiththeage，myometrialin- vasionandlymphnodemetastasis(P0．05)．ThepositiveexpressionofFaswascorrelatedwihthistoloyg rgadenad lmyphnodemetastasis(P0．05)，butnotwiththeage，clinicalstageandmyometrialinvasion(P0．05)．Condu- sion：Th eexpressionofFAP一1was significantlycorrelatedwithresistanceagainstFas—mediatedapoptosis。contfibu— tingtothecarcinogenesisandsubsequentprorgessioninendometrial carcinoma．FAP一1andFasmightbeamrakerof biologicalbehaviorandreferenceforendometrlal carcinomagenetherapy． 【Keywords】FAP一1；Fas／Fas—L；endometrialneoplasms；immunohistochemistry ModemOneoloyg 2010，18(08)：1608—1611 【摘要】 目的：研究Fas相关磷酸酯酶 一1(FAP一1)和Fas在子宫内膜癌中的表达及其与临床病理特征问的