人类免疫缺陷病毒丙型肝炎病毒混合感染者抗丙型肝炎病毒治疗的进展.PDFVIP

540 J Clini Hepatol, May 2011, Vol.27, No.5 综述 人类免疫缺陷病毒/丙型肝炎病毒混合感染者 抗丙型肝炎病毒治疗的进展 田 地，徐小元 (北京大学第一医院感染疾病科，北京 100034) 摘要：由于人类免疫缺陷病毒(HIV)和丙型肝炎病毒(HCV)有相 同的传播途径 ，HIV/HCV混合感染现象十分普遍 ，已成为 严重的公共卫生问题。高效抗逆转录病毒治疗(HAART) 的应用显著减少了与HIV感染相关的发病率和病死率 ，而HCV混合感染 引起的慢性肝脏疾病 日益成为HIV/HCV混合感染者发病和死亡的重要因素。HIV/HCV混合感染者HCV相关肝病的风险增加 ， 有效的抗HCV治疗对延长这一人群的生存期至关重要。本文就抗HCV治疗对象的评估 、治疗时机 的选择 、治疗的方法、治疗监 测和疗效评估 以及治疗注意的问题作一综述。 关键词：HIV感染 ；肝炎 ，丙型 ；肝炎病毒属 ；重叠感染 中图分类号： + 文献标识码： 文章编号： （ ） R512.6 3 A 1001-5256 2011 05-0540-05 Treatment of hepatitis C virus infection in HIV/HCV co-infected patients TIAN Di, XU Xiao-yuan. (Department of Infectious Disease, the First Hospital of The Peking University, Beijing 100034, China) Abstract: Duo to increasing prevalence and complex patient management, coinfection of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is a substantial medical and public health concern. The development of highly active antiretroviral therapy (HAART) results in a dramatic decrease in morbidity and mortality among HIV-infected patients, and liver disease caused by chronic infection with HCV has become an increasingly important cause of morbidity and mortality among HIV-infected patients parenterally with HCV. Since HIV/HCV coinfection is prevalent and increases the risk of HCV-associated liver disease, effective treatment for HCV is critical for the long-term survival of this group of patients. The assessment of coinfected patients, the time of treatment, the therapy of HCV infection, monitoring of coinfected patients before and during therapy of HCV infection, evaluation of the response to treatment, the caution during treatment are stated briefly.