前列腺癌中tmprssets基因融合及机制研究进展-遗传.pdfVIP

HEREDITAS (Beijing) 2011 2 , 33(2): 117 ―122 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2011.00117 前列腺癌中TMPRSS2-ETS基因融合及机制研究进展 1, 2 1 1 郭晓强 , 桂耀庭 , 蔡志明 1. , , 518036; 2. , 050081 超过50% 的前列腺癌中存在跨膜丝氨酸蛋白酶2(TMPRSS2)和E26(ETS) 转录因子间的基因融合, 其中 TMPRSS2-ERG 最为常见。TMPRSS2-ERG 基因融合造成的ERG 过表达参与了前列腺的癌变。雄激素受体结合 和遗传毒性胁迫共同诱导了染色体的靠近和TMPRSS2-ETS 的基因融合。TMPRSS2-ERG 基因融合可作为前列腺 癌诊断的一种生物标志物, 并可通过病人尿液检测来实现。文章对 TMPRSS2-ETS 基因融合的特征、融合及致 癌及临床应用进行了综述。 前列腺癌; 基因融合; 跨膜丝氨酸蛋白酶2; E26; 融合机制 The progress of TMPRSS2-ETS gene fusions and their mechanism in prostate cancer 1, 2 1 1 GUO Xiao-Qiang , GUI Yao-Ting , CAI Zhi-Ming 1. The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen 518036, China; 2. Department of Biochemistry, Bethune Military medical College, Shijiazhuang 050081, China Abstract: The gene fusions between transmembrane protease serine 2 (TMPRSS2) and E26 (ETS) transcription factors are present in over 50% of patients with prostate cancer. TMPRSS2-ERG is the most common gene fusion type. The ERG overexpression induced by TMPRSS2-ERG gene fusion contributes to the development of prostate cancer. Both androgen receptor binding and genotoxic stress induce chromosomal proximity and TMPRSS2-ETS gene fusions. TMPRSS2-ERG gene fusion functions as a biomarker for prostate cancer, which can be easily detected in urine. This review focuses on the characteristics, oncogenic and rearranged mechanism, and clinical application of TMPRSS2-ETS gene fusions. Keywords: prostate cancer; gene fusion; transmembrane protease serine 2 (TMPRSS2); E26; rearranged mechanism ,