在中国汉族人群中,以家系传递肿瘤坏死因子a-308AG单核苷酸多态性与抽动秽语综合征(英文).pdfVIP

在中国汉族人群中,以家系传递肿瘤坏死因子a-308AG单核苷酸多态性与抽动秽语综合征(英文).pdf

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在中国汉族人群中,以家系传递肿瘤坏死因子a-308AG单核苷酸多态性与抽动秽语综合征(英文)

417 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.3 FEB.2011 · · Family-based transmission analysis of -308A/G polymorphism in TNF-alpha with Tourette syndrome in Chinese Han population △ QI Feng -guang, WANG Pei-lin , WANG Xiu -hai, LIU Shi-guo Dep artment of Biology, Medical College of Qingdao University, Qingdao, 26602 1, China) ( ABSTRACT Obj ective: To investigate the relationship between -308A/G polymorphism in the promoter region of TNF-alpha and susceptibility to Tourette syndrome in Chinese Han population. Methods: Genetic distribution of -308A/G polymorphism in TNF-alpha of 91 trios were evaluated by using case-control study method based on nuclear family including transmission disequilibrium test (TDT), haplotype relative risk (HRR) and haplotype-based haplotype relative risk(HHRR). Results: -308A/G polymorphism in TNF-alpha of 91 2 trios was in accordance with Hardy-Weinberg equilibrium in genotype distribution. (x 3.84;P0.05). There was not biased transmission of allele from parents to their affected offspring in our informative samples in -308A/G polymorphism. HRR and HHRR had not any as- sociations with TS at -308A/G polymorphism in TNF-alpha. Conclusion: -308A/G polymorphism in the promoter region of TNF-alpha was not associated with susceptibility to Tourette syndrome in Chinese Han population. Key words: Tourette syndrome; TNF-α; TDT; HRR;HHRR Chinese Library Classification(CLC): R394-33 Document

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