骨质疏松症论文：鲑鱼降钙素治疗绝经后骨质疏松症的临床观察.docVIP

骨质疏松症论文：鲑鱼降钙素治疗绝经后骨质疏松症的临床观察 【中文摘要】了解鲑鱼降钙素用于绝经后骨质疏松症的治疗作用。方法：选择年龄60-80岁绝经后女性共60名,全部患者符合以下标准：(1)年龄55岁；(2)自然绝经≥3年；(3)有负重性或(和)自发性的周身或胸、腰痛；或轻微损伤所致的骨折史；(4)骨密度低于同年龄组的1标准差或年轻人峰值的2个标准差；研究对象以就诊时间按随机表顺序分到对照组(钙剂+维生素D)和治疗组(鲑鱼降钙素+钙剂+维生素D)。两组间在性别、年龄、临床表现等方面无显著性差别,具有可比性。行相同的饮食指导,药物使用的计量为：鲑鱼降钙素喷鼻剂50IU/d；元素钙600mg和维生素D125U。研究时间为24周。于0周、12周和24周观察患者临床疗效：应用Challenger “99”双能X光骨密度测量仪测量第2-4腰椎(L2-4)以及股骨颈、Wards三角以及大转子等处的骨密度(BMD)。骨密度(BMD)单位(g/cm2),于0周、24周进行。于0周、12周和24周采用放免法测定空腹血骨钙素(BGP)；采用ELISA测定骨碱性磷酸酶(AKP)。结果：治疗24周后,治疗组与治疗前相比,血清骨钙素的值明显升高,腰椎2-4椎体的BMD升高,有显著性差异(P0.05)。而碱性磷酸酶的值降低,有显著性差异(P0.05)。对照组与治疗前相比,血清骨钙素和AKP的值改变不明显,BMD各部位变化不明显。治疗组与对照组相比,血清骨钙素和BMD的值明显升高,有显著性差异(P0.05),而碱性磷酸酶的值降低,差异有显著性(P0.05)。结论：鲑鱼降钙素加钙剂及维生素D联合治疗绝经后骨质疏松症能抑制骨吸收,增加骨矿含量,从而有效治疗骨质疏松症。 【英文摘要】[]:Understand the therapeutic action of the calcitonin to the osteoporotic post-menopause.[Methods]:Select sixty of the aging of sisty to eighty post-menopause female,most of them fit below standard:(1)the agefifty-five; (2)nature menopausethree years;(3)have the weight-bearing or(and) idipathic whole body or breast、lumbago;or little damage to result bone fracture case history;(4)BMD be lower than the same age group one standard error or two standard error of the young people peaked. All 60 female patients were randomly allocated into two groups according the time them enter the trial. Control Group:(vitamin D and calcium).Test Group:(Salmon Calcitonin calcium and vitamin D)。The two groups have not significant difference in the sex、age、clinical situation and so on,possess comparability. All patients were treated with the same diet guide, the metrology of drug use:Salcatonin Nasal Spray (50IU/d); calcium carbonate (600 mg/day) and vitamin D(125 IU/d),the study consists 24 weeks. Observe the therapeutic effect at 0 week、12th week、and 24th week; Using Challenger “99” the double X-light energy measurement of bone mineral density penetron to measure the BMD of lumber spine (L2-4)、femur neck、Wards triangle、greater trochanter and forearm. BMD unit(g/c