右美托咪定联合地塞米松对单肺通气手术患者对肺损伤以及炎性因子的影响.docVIP

右美托咪定联合地塞米松对单肺通气手术患者对肺损伤以及炎性因子的影响 陈显宇 四川省林业中心医院麻醉科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的:探讨在单肺通气手术过程中运用右美托咪定联合地塞米松全身麻醉的麻醉效果以及对肺部损伤和炎性因子的影响。方法:对2012年12月2015年12月期间在我院进行单肺通气手术的120例患者的病历资料进行回顾性分析。将采用右美托咪定联合地塞米松全身麻醉的60例患者设为观察组。将只进行右美托咪定麻醉的60例患者设为对照组。对比各时间点相关炎性因子的变化、同时对比两组患者各项麻醉效果及手术指标, 对比两组患者肺损伤指标。结果:两组患者手术期间血清TNF-α、IL-10、TL-Iβ逐渐升高;T2后观察组TL-Iβ、TNF-α显著低于对照组, T3后观察组IL-10显著高于对照组;观察组MPO、MOD、XOD均显著低于对照组;两组患者输液总量、住院天数、OLV时间、机械通气时间、手术时间无明显差异, 观察组输血总量显著低于对照组。结论:相较于单独使用右美托咪定麻醉, 联合使用地塞米松能有效减轻氧化应激指标, 减轻炎性反应对肺的损伤。 关键词： 右美托咪定; 地塞米松; 单肺通气手术; 肺损伤; 炎性因子; 作者简介：陈显宇, E-mail:434800927@ 收稿日期：2017-09-02 Effects of Dexmedetomidine Combined with Dexamethasone on Lung Injury and Inflammatory Factors of Patients Receiving One-lung Ventilation Surgery Chen Xian-yu Department of Anesthesiology, Sichuan Forestry Center Hospital; Abstract： Objective To discuss the effects of dexmedetomidine combined with dexamethasone as general anesthesia and their effects on lung injury and inflammatory factors in the one-lung ventilation surgery. Methods The datum of cases of 120 cases of Patients receiving one-lung ventilation surgery in our hos Pital since December 2012 to December 2015 were reviewed and analyzed.50 cases of Patients receiving general anesthesia of dexmedetomidine combined with dexamethasone were set as observation group, while 50 cases of Patients receiving only dexmedetomidine anesthesia were set as control group. Comparisons were made for variations of related inflammatory factors between different time points. Meanwhile, various anesthesia effects and operation indicators between patients of two groups were compared, so did the lung injury indicators of patients in two groups. Results During the surgery, the serum TNF-α, IL-10 and TL-Iβ of patients in both grou P increased, while the TLIβ and TNF-α of Post-T2 observation group were significantly lower than those of control group, and the IL-10 of the Post-T3 observation group were obvi