2011—2012年耐甲氧西林金黄色葡萄球菌的临床分布与耐药性分析.docVIP

精品论文 参考文献 2011—2012年耐甲氧西林金黄色葡萄球菌的临床分布与耐药性分析 陈海秋 高晓林（通讯作者） （内蒙古林业总医院内分泌科 内蒙古牙克石 022150） 【摘要】目的 调查医院2011年1月—2012年12月分离的耐甲氧西林金黄色葡萄球菌的耐药趋势，为临床治疗提供依据。方法 收集送检标本中分离的耐甲氧西林金黄色葡萄球菌，按照全国临床检验规程分离，并采用美国临床实验室标准化研究所（CLSI）推荐的K-B法进行药敏试验。结果 共分离出22株耐甲氧西林金黄色葡萄球菌，以痰标本分离率最高，占68.18%，其次分别是分泌物、清洁中段尿分别占：18.18%、13.64%；耐甲氧西林金黄色葡萄球菌对利奈唑烷、万古霉素的耐药率为0，对青霉素、甲氧西林的耐药率达到100%，对林可酰胺类、氨基糖甙类的耐药率也达70%、50%以上。结论 对耐甲氧西林金黄色葡萄球菌进行及时鉴定与药敏分析，把握其耐药趋势，可有效指导临床合理用药。 【关键词】 耐甲氧西林金黄色葡萄球菌 临床分布 耐药性 【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2013）30-0227-02 Clinical distribution of MRSA and analysis of drug resistance from 2011 to 2012 Chen haiqiu （Endocrinology department of Inner Mongolia General Forestry Hospital,Inner Monglia, Yakeshi 022150,China） 【Abstract】 OBJECTIVE To investigate the tendency of drug resistance of MRSA isolated from Jan 2006 to Dec 2010, so as to provide reliable evidence for clinical treatment. METHODS The MRSA strains isolated from the submitted specimens were collected, the pathogens were isolated and identified according to the national clinical test procedures. The antimicrobial susceptibility testing was performed by using K-B method. RESULTS Altogether 22 MRSA strains have been isolated, 68.18% of which were derived from sputum, and the rest of the pathogens were successively derived from the secretion 18.18% and the urine 13.64%; the drug resistance rates of MRSA against linezolid and vancomycin 0%, the resistance rate to penicillin and methicillin was 100%, the resistance rate to lincosamides and aminoglycosides were higher than 50% and 70%. CONCLUSION It is effective to direct the reasonable clinical medication through identifying MRSA strains and performing the drug susceptibility testing in a timely manner as well as grasping the tendency of drug resistance. 【Key words】 MRSA Clinical distribution Drug resistance 耐甲氧西林金黄色葡萄球菌（MRSA）已成为医院和社区常见的病原菌，其致病能力强，耐药谱广，而且对多种抗菌药物敏感性呈逐渐下降的趋势，已成为医学界关注的焦点问题[1]。本研究对我院2011年1月—201