地佐辛用于骨科术后自控静脉镇痛的临床研究.docVIP

精品论文 参考文献 地佐辛用于骨科术后自控静脉镇痛的临床研究 金春姬 邹吉贺 周锦（通讯作者） 　　（沈阳军区总医院麻醉科 沈阳 110016） 　　【摘 要】目的：研究地佐辛用于骨科患者术后自控静脉镇痛的临床疗效。方法：120例骨科手术患者，随机分为观察组和对照组，观察组应用地佐辛0.8 mg/kg+0.9%生理盐水100 ml，对照组应用芬太尼16mu;g/kg+0.9%生理盐水100 ml进行镇痛，均采用自控镇痛（PCA）泵 (100 m1)以LCP模式(负荷剂量3 m1+持续剂量2 m1／h+PCA 每次0．5 m1)进行镇痛。观察记录患者1 h、6h、12h、24h、48h的疼痛评分、镇静评分、舒适度评分、术后48 h内有效的PCA按压次数。结果：术后各观察时间点的疼痛评分、镇静评分、舒适度评分比较，差异无统计学意义(Plt;0.05)。对照组恶心呕吐、皮肤瘙痒、嗜睡、尿潴留、呼吸抑制、低血压等发生率明显高于观察组。结论：地佐辛、芬太尼用于骨科术后自控静脉镇痛均可靠效果，而地佐辛较舒芬太尼的不良反应少，是理想的骨科手术患者术后自控静脉镇痛药物。 　　【关键词】骨科手术；地佐辛；自控静脉镇痛 　　【中图分类号】R614 【文献标识码】B 【文章编号】1003-5028（2015）8-0698-02 　　Clinical study of analgesic effects 　　of dezocine used for pastoperative PICA in orthopaedic surgery patients 　　【Abstract】Objective：study clinical efficacy of dezocine used for postoperative PICA in orthopaedic surgery patients. Methods：120 cases of orthopedic surgery were randomly divided into two groups and the control group, observation group Dezocine 0.8 mg / kg + 0.9% saline 100 ml, the control group fentanyl 16mu;g / kg + 0.9% saline 100 ml analgesia, are used controlled analgesia (PCA) pump (100 m1) to LCP mode (loading dose of 3 m1 + continuous dose of 2 m1 / h + PCA every 0.5 m1) analgesia. Observation records of patients 1 h, 6h, 12h, 24h, 48h pain scores, sedation scores, comfort score within 48 h after effective PCA pressing times.Results：After each observation time point of pain scores, sedation scores, comfort scores, the difference was not statistically significant (P lt;0.05). Control nausea and vomiting, pruritus, somnolence, urinary retention, respiratory depression, hypotension, were significantly higher than in the observation group. Conclusion：Dezocine fentanyl intravenous patient controlled analgesia orthopedic reliable Dezocine less adverse reactions than the sufentanil is ideal orthopedic surgery patients were controlled intravenous analgesia. 　　【Key words】orthopaedic surgery;Dezocine;PCIA 　　骨科手术后患者存在不同程度的疼痛、制动情况，不仅影响伤口愈合，而且严重时威胁患者生命安全[1]。合理的镇痛药物配伍，有效保持患者氧代谢水平和血流动力学稳定，消除或者缓解疼痛