多重耐药菌呼吸道感染临床随机对照研究.docVIP

精品论文 参考文献 多重耐药菌呼吸道感染临床随机对照研究 杜蓉 王东 吴友茹 徐维国 陈明勇 王蓉 李惠 　　（绵阳市中心医院 四川 绵阳 621000） 　　【摘 要】目的：比较多重耐药菌呼吸道感染不同处理措施的临床效果。 方法：采用随机单盲对照试验，观察组采用非抗生素抗感染治疗措施，对照组采用抗生素抗感染治疗措施，疗程7-10 d，分析比较患者临床疗效、影像学改变、痰培养转阴率、不良反应、治疗费用等方面的差异。结果：共入选病例113例，观察组54例，对照组59例，两组在临床疗效、痰培养转阴率等方面比较，P值分别为0.067、0.071，均gt;0.05，差异无统计学意义。在不良反应、药物费用等方面比较，P值分别为0.042、0.025，均＜0.05，差异有统计学意义。结论：在多重耐药菌呼吸道感染中使用抗生素并非有益。 　　【关键词】多重耐药菌； 呼吸道感染；随机对照研究 　　【中图分类号】R373.1 【文献标识码】B 【文章编号】1003-5028（2015）7-0160-02 　　 　　Randomized controlled clinical trial for Respiratory tract infections of multi-resistant bacteria 　　DU Rong, WANG Dong, WU YouRu, , XU WeiGuo，CHEN MingYong，WANG Rong，LI Hui 　　Respiratory medicine , Central Hospital of Mianyang City, Mianyang 621000, China 　　Corresponding author：WU YouRu, Email：dur1020@126.com 　　【Abstract】Objective: To compare the clinical effects of different treatments in respiratory tract infections by multi-resistant bacteria. Methods: We performed a randomized, single-blinded, controlled clinical trial, observer group: non-antibiotic anti-infective treatment ; control group: antibiotics anti-infection treatment; treatment for 7-10 d, analysis of comparative clinical efficacy, radiographic improvement, sputum culture negative rate, conversion rate and cost of treatment differences. Results: 113 cases were enrolled, 54 of observer group, 59 of control group; The P values were 0.067、0.071 in the two groups for the clinical efficacy, sputum culture negative rate. All of them aregt; 0.05, the difference was not statistically significant. The P values were 0.042,0.025, for adverse reactions and drug costs, lt;0.05, the difference was statistically significant. Conclusion: It is not must be helpful that use of antibiotics in multi-drug resistant respiratory infections. 　　【Key words】 Multidrug resistant bacteria; Respiratory tract infections; Randomized controlled study。 　　多重耐药菌是指对三种及三种以上抗生素耐药的细菌，常见为医院内感染，细菌构成以非发酵革兰氏阴性菌、肠杆菌科细菌和金黄色葡萄球菌等多见；其大多属于条件致病菌，常在免疫力低下、长期住院的患者的呼吸道、尿道及一些植入体内的开放或半开放性