某院623例药品不良反应报告分析.docVIP

某院623例药品不良反应报告分析 黄月莹 高欣涛 刘弘 解放军152医院药学部 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 了解某院药品不良反应 (ADR) 发生的一般规律及特点, 为临床合理用药提供参考。方法 采用回顾性分析方法, 对某院2011-01-01—2015-12-31收集的623例填报完整和有分析评价的ADR报告进行分析。结果 ADR发生的男、女比例为0.99∶1;静脉滴注引发ADR的比例最高 (88.43%) ;涉及药品种类以抗微生物药最多 (39.97%) ;ADR累及器官或系统最多的是皮肤及其附件 (44.66%) 、全身性损害 (21.96%) 等。结论 医院应积极、规范地开展ADR监测和上报工作, 提高患者的用药安全;药学部门要加大ADR知识的培训, 提高医护人员的重视度和积极性。 关键词： 药品不良反应; 回顾性分析; 监测; 收稿日期：2017-02-22 Analysis on 623 cases reports with adverse drug reaction in a hospital of PLA HUANG Yue-ying GAO Xin-Tao LIU Hong Department of Pharmacy, No.152 Central of PLA; Abstract： Objective To investigate the feature and regularity of adverse drug reactions (ADRs) occurred in authors hospital so as to provide a reference for rational medication in clinic. Methods All the 623 cases of ADRs collected in the hospital from January 1, 2011 to December 31, 2015 which were reported completely and had obtained analysis evaluation were analyzed retrospectively. Results Among the 623 ADRs cases, the male to female was 0.99 ∶1, the highest percentage belonged to intravenous drip was 88.43%. The antimicrobial drug was the most drug varieties involved (39.37%) . The most common involved organs/systems of ADRs were skin and appendages disorders (44.66%) , followed by systemic lesions (21.96%) . Conclusion The monitoring and reporting ADRs should be carried on positively and normatively in hospital so that to improve the security of using drugs.Pharmacy department should reinforce the training of ADRs knowledge to improve the attention and motivation of the medical staff. Keyword： Adverse drug reaction; Retrospective analysis; Monitor; Received： 2017-02-22 药品不良反应 (adverse drug reaction, ADR) 是指合格药品在正常用法用量下出现的与用药目的无关或意外的有害反应[1]。ADR存在巨大的安全隐患, 与医疗质量及医疗安全息息相关。通过对笔者所在医院5年来收集的623例ADR报告进行整理、统计、分析, 进一步了解和掌握ADR的一般规律和特点, 为临床合理用药提供依据, 对减少ADR的发生率起到积极的作用。 1 资料与方法 通过“药品不良反应监测系统”收集笔者所在医院2011-01-01—2015-12-31由科室医师和护士上报的ADRs报告, 共623例, 并对患者性别与