妊高症患者治疗前后血浆ET-1、D-D和血清APN水平检测的临床意义.docVIP

精品论文 参考文献 妊高症患者治疗前后血浆ET-1、D-D和血清APN水平检测的临床意义 张俊芳1 唐国建2 (1金坛市直溪中心卫生院检验科 江苏金坛 213200) (2金坛市第一人民医院检验科 江苏金坛 213200) 【摘要】目的 探讨妊高症患者治疗前后血浆ET-1、D-D和血清APN水平的变化及临床意义。方法　应用放射免疫分析法、酶联法和免疫比浊法对32例妊高症患者进行了治疗前后血浆ET-1、D-D和血清APN水平检测，并与35名正常健康人作比较。结果 妊高症患者治疗前血浆ET-1、D-D水平非常显著地高于正常人组（P＜0.01），而血清APN水平又非常显著地低于正常人组（P＜0.01），经2周治疗后则与正常人比较无显著差异（P＞0.05）,且血清APN水平与ET-1，D-D水平呈显著负相关（r=-0.6814、-0.5944、P＜0.01）。结论 检测妊高症患者治疗前后血浆ET-1、D-D和血清APN水平的变化对了解病情、探讨其发病机理、预防和指导用药均有重要的临床意义。 【关键词】妊娠高血压综合征 内皮素-1 脂肪细胞因子 D-D二聚体 【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2013）24-0093-02 Clinical significance of Determination of changes of Plasma ET-1,D-D and Serum APN levels after treatment in patients with pregnancy induced hypertension (PIH) ZHANG JunFang. (Department of Clinical Laboratory，Jintan Central Hospital，Jiangsu Jintan 213200，China) 【Abstract】Objective To explore the Clinical Significance of Determination of changes of plasma ET-1.D-D and serum APN levels after treatment in patients with pregnancy induced PIH. Methods Plasma ET-1(with RIA), plasma D-D(with immutability) serum APN(with ELISA ) levels were determined In 32 patients with PIH both before and after treatment,and 35 controls Results Before treatment plasma ET-1 and D-D levels were significantly higher than those in controls (P lt; 0.01), but serum APN levels were significantly lower (P lt; 0.01), after treatment for 2 weeks,the difference between the levels in patients and controls were not significant (P gt; 0.05), serum APN levels were negatively correctly of plasma ET-1. D-D levels （r=-0.6814、-0.5944、P＜0.01）.Conclusions Detection of plasma ET-1.D-D and serum APN levels were helpful to the assessment of the diseases process. 【Key words】 Pregnancy Induced hypertension(PIH) Endothelin-1(ET-1) Adiponectin(APN) D-Dimer(D-D) 多年来，PIH的病因和发病机制尚未得到一个圆满的解释。但近年来的研究表明，PIH的发生与发展与血管内皮细胞及血管细胞因子的合成和障碍发生有关[1]。多数学者认为其发病与免疫功能失衡、炎症过度激活有关，从而提出了内皮细胞激活、损伤及免疫失衡等学说[2]。D-D二聚体的检测是反映体内高凝状态和继发性纤溶亢进的标志物之