蠕虫感染与过敏性和自身免疫性疾病.pdfVIP

Chinese Journal of Zoono ses DOI 10 3969cjz issn 1002 2694 2014 12 017 j T B R383 A 1002 2694 2014 12 1252 05 Effect of helminth infection on allergic and autoimmune diseases Y A N G Wei ing T IA N Fang H U Xueli p Dep artment of Pathogen B iology and I mmunology M e d ical College Y angz hou Univ e rs ity Y angz hou China ABSTRACT M any studies show that helminthderived molecules can induce immunoregulatory cells to form immune net w orkmediated immune thereby inhibiting allergic and autoimmune diseases Helminth parasites can induce immune cell activa tion and produce cy tokine And parasites play an inhibitory eff ect to aff ect other immune related diseases How ever the associ ation betw een helminths infections and immune related diseases does not alw ay s have an unequivocal outcome While some hel minths inf ections protect against allergic diseases other helminth can exacerbate this immunopathology KEY WORDS helminth inf ection allergic diseases autoimmune diseases regulatory T cells regulatory B cells Supported by the National Natural Foundation of China Nos and H Corresponding author Yang Wei ing Email w pyang zu edu cn p y 1 T h ILILILILIL T T reg s B IL Breg s DCs