负反馈动力学与调控生物网络中的振荡行为.pdfVIP

Feedback and Activitiesin Negative DynamicsOscillatory Regulatory Networks Biological ShiweiYan Nuclear Normal Energy (InstituteofLow Physics,BeijingUniversity,Beijing 100875,China) yansw@bnu．edu．cn Abstract：Therecent onthe ofacommon network experimentsdynamics biological andMdm2feedback shownmuchthedifferent motif,p53 loop，have oscillatory behaviorsfortheactivitiesof and Mdm2 inindividualandin p53 proteins population of thenonlinear inthe feedback cells．Exploitingdynamicsnegative loop，wepropose astatistical modelwith todescribesuchthedifferent signal—response aiming behaviorsinaunified the andthe oscillatory way．Throughanalyzingstability mechanism ofthesolutions ofmodel obtainacriterionof sensitivity equations，we themodel forthestable solutions． defining parameters oscillatory feedback and Keywords：p53-Mdm2interaction，negativeloop，sustained damped oscillatorydynamics I．D盯RODUCnON attentionshavebeen tothe Recently,intensive paid regulatedoscillatory of the oractivitiesofthecommonnetworkmotif of dynamicsexpressions composed thetumor andits