重症肺炎患儿病原菌分布特点及耐药性分析.docVIP

重症肺炎患儿病原菌分布特点及耐药性分析 王接新 单小鸥 张春霞 叶小君 罗越 金佳慧 温州医科大学附属第二医院儿童内分泌科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 探讨和分析重症肺炎患儿病原菌分布特点及抗菌药物耐药趋势。方法 选择2014年1月-2016年12月期间医院收治的218例重症肺炎患儿作为临床研究对象, 并分别对重症肺炎患儿的病原菌分布特点及抗菌药物耐药趋势进行统计分析。结果 218例重症肺炎患儿中共检出病原菌281株, 以革兰阴性菌为主, 共147株占52.31%;以痰液检出为主, 共208株占74.02%;主要革兰阴性菌对阿米卡星、亚胺培南、头孢哌酮/舒巴坦、美罗培南均表现出较高的耐药性, 耐药率均80.00%, 对头孢唑林和头孢噻肟则均表现出较低的耐药性, 耐药率均25.00%。结论 重症肺炎患儿病原菌分布以革兰阴性菌为主, 治疗过程中应根据病原菌的分布特点及耐药趋势科学合理选择抗菌药物。 关键词： 重症肺炎患儿; 病原菌分布; 抗菌药物; 耐药; 收稿日期：2017-08-15 Distribution characteristics of pathogens and analysis of drug resistance in children with severe pneumonia WANG Jie-xin SHAN Xiao-ou ZHANG Chun-xia YE Xiao-jun LUO Yue JIN Jia-hui The Second Affiliated Hospital of Wenzhou Medical University; Abstract： OBJECTIVE To probe into and analyze distribution characteristics and drug resistance trend of pathogens in children with severe pneumonia.METHODS A total of 218 children with severe pneumonia from Jan.2014 to Dec.2016 were selected as the clinical subjects.The distribution characteristics and drug resistance trend of pathogens in children with severe pneumonia were statistically analyzed.RESULTS There were 281 pathogens detected from 218 children with severe pneumonia, which were mainly 147 strains of gram-negative bacteria, accounting for 52.31%.The main source of pathogens was sputum, which were 208 strains, accounting for 74.02%.The major gram-negative bacteria showed high resistance to amikacin, imipenem, cefoperazone/sulbactam and meropenem, and the resistant rates were all more than 80%, while had low resistance to cefazolin and cefotaxime, with the resistant rates lower than 25%.CONCLUSION Pathogen distribution of children with severe pneumonia is mainly gram-negative bacteria.In the course of treatment, we should scientifically and rationally select antibiotics based on the distribution of pathogens and drug resistance trend. Keyword： Children with severe pneumonia; Distribution of pathoge