体外中药干预骨髓间充质干细胞向心肌细胞分化的研究进展.pdfVIP

2 0 1 4 年 2 月 第 4 卷 第 4 期 ·综    述 · 体外中药干预骨髓间充质干细胞向 心肌细胞分化的研究进展 路  娟    胡继宏（审校） 甘肃中医学院公共卫生学院，甘肃兰州 730000 [摘要] 骨髓间充质干细胞具有自我更新、增殖和多向分化的潜能，骨髓间充质干细胞在体外可通过化学药 物及中药干预诱导分化为心肌细胞，将其应用于治疗缺血性心脏病，可减少梗死面积，改善心功能，为心脏 病的治疗开辟了新途径。大量研究表明，中药在骨髓间充质干细胞增殖和定向分化过程中具有促进作用， 不仅可在体内作用于骨髓间充质干细胞促进其增殖、分化，还可通过影响体外微环境促进其功能的建立与 存活。 [关键词] 中药；骨髓间充质干细胞；心肌细胞；干预；分化 [中图分类号] R259      [文献标识码] A      [文章编号] 2095-0616 （2014 ）04-39-04 Research progress of the intervention of traditional Chinese medicine in vitro on the differentiation of mesenchymal stem cells to myocardial cells LU  Juan    HU  Jihong  School of Publish Health, Gansu College of Traditional Chinese Medicine, Lanzhou 730000, China [Abstract] Mesenchymal stem cells have the potentials of self-renewal, proliferation and multi-directional differentiation, and they can be induced to differentiate into myocardial cells in vitro by interventions of chemical drugs and traditional Chinese medicine. The differentiation can be applied in the treatment of ischemic heart disease, which helps reduce infarct area, improve heart functions and thus open up a new treatment method for heart diseases. Plenty of studies reveal that traditional Chinese medicine functions as promoters in the process of proliferation and committed differentiation of mesenchymal stem cells, which not only promotes the proliferation and differentiation of mesenchymal stem cells in vitro, but also facilitates the establishment and survival of cell functions by affecting external micro-environment. [Key words] Traditional Chinese medicine; Mesenchymal stem cells; Myocardial cells; Intervention; Differentiation 心血管疾病是现代社会危害人类健康的主要 供了新途径。5- 氮胞苷（5-Azacytidine，5-Aza）是 疾患，急性心肌梗死是心血管疾病中最常见和多发