急性颅脑损伤患者血清BNP、NT和血浆ET-1水平检测的临床意义.docVIP

精品论文 参考文献 急性颅脑损伤患者血清BNP、NT和血浆ET-1水平检测的临床意义 刘宇梁 伏光辉 李凤利 （连云港市东方医院神经外科 222042） 【摘要】目的 探讨急性颅脑损伤患者血清BNP、NT和血浆ET-1水平的变化及临床意义。方法　应用放射免疫分析法对34例急性颅脑损伤患者进行血清BNP、NT和血浆ET-1水平测定并与35名正常健康人作比较。结果　急性颅脑损伤患者血清NBP水平显著低于正常人组（Plt;0.01)，而血清NT和血浆ET-1水平又非常显著地高于正常人组（Plt;0.01)，血清BNP水平与NT、ET-1水平呈显著负相关（r=-0.4185，-0.4921，Plt;0.01）。结论　检测急性颅脑操作患者血清NBP、NT和血浆ET-1水平的变化有助于疾病的诊断和评估。具有重要的临床价值。 【关键词】急性颅脑损伤 脑钠肽 神经降压素 内皮素-1 【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2013）26-0110-02 Clinical significance of measurement of changes of serum BNP NT plasma ET-1 levels in patients with acute craniocerbral injury Oriental Hospital of Lian Yungang (222042), Liu Yu-liang 【Abstract】 objective: To explore the clinical significance of measurement of changes of serum BNP NP and plasma ET-1 levels in patients with acute craniocerebral injury . Methods: Serum BNP NT and plasma ET-1 content were determined with RIA in 34 patients with acute craniocerebral injury and 35 controls . Results: Serum BNP levels were significantly lower than those in controls (Plt;0.01) but serum NT and plasma ET-1 content were significantly higher than those in controls(Plt;0.01) ，serum BNP levels were negatively correlateed with NT ET-1 level (r=-0.4185,-0.4921,Plt;0.01). Conclusion :Detection of serum BNP NT and plasma ET-1 levels was helpful for assessment of the diseases process and autcom predictimin patient with acute craniocerebral injury must be of important clinical value. 【Key words】 Acute craniocerebrae injury Brain natriaritic reptide (BNP) Neurotensin(NT) Endothelin-1(ET-1) 急性颅脑损伤后常引发一系列神经内分泌的改变，为了探讨急性颅脑损伤患者血清BNP NT和血浆ET-1水平的变化，我们对临床上明确诊断的急性颅脑损伤患者进行了BNP NT和ET-1水平的测定，旨在探讨其在临床上的应用价值，结果报告如下： 1 资料与方法 1.1临床一般资料. 1.1.1病人组：34人（男30，女4）均为我院神经外科经临床明确诊断的患者（包括体征、CT或MRI和实验室的检查项目）以进一步的明确诊断，伤前无神经系统及心、肝、肾等重要脑器疾患，肝、肾功能正常。 1.1.2正常人祖：35人（男28女7），均为我院体检中心经健康体检合格的正常人，无心、肝、肺、肾、等重要脏器疾患，肝肾功能正常，亦无神经系统疾患。 1.2方法 1.2.1血浆ET-1和血清BNP