惠州蓝田瑶族人群盐敏感性与血压关系的研究.docVIP

精品论文 参考文献 惠州蓝田瑶族人群盐敏感性与血压关系的研究 张金强 罗应超(通讯作者) 陈友良 　　(广东省惠州市龙门县人民医院 516800) 　　【摘要】目的 探讨蓝田瑶族盐敏感性的血压差异及其对肾脏的损害。方法 收集1030名符合条件的瑶族居民，以相应的1280名汉族居民为对照，统一进行低盐饮食(摄盐量3g/dx7d)继而高盐饮食(摄盐18g/dx7d)干预，定时监测血压，收集两个阶段的尿液及血液标本，检测血beta;2-微球蛋白(beta;2-MG)、尿beta;2-MG、尿微白蛋白(Alb)、尿肌酐(Cr)及尿Alb/Cr等指标。结果 瑶族盐敏感(SS)者检出率为16.5%，明显低于汉族(P lt;0.05)。SS者从低盐到高盐饮食变化后，收缩压或舒张压均明显上升，盐敏感指标△H-LMABP和△H-BMABP分别为6.9plusmn;4.3mmHg及6.3plusmn;4.4mmHg，均高于盐不敏感(SR)组的0.4plusmn;4.2mmHg及1.0plusmn;3.7mmHg(P lt;0.01)。高盐饮食后，SS者的尿beta;2-MG和尿Alb/Cr也明显高于SR者(Plt;0.05)，但其上升幅度小于汉族SS者(Plt;0.05)。结论 蓝田瑶族的盐敏感性及高盐对肾脏损害程度具有自身的特点，可能与其特殊的饮食习惯及高血压相关基因多态性有关。 　　【关键词】盐敏感 血压 膳食盐 干预试验 少数民族 　　【中图分类号】R199 【文献标识码】A 【文章编号】2095-1752（2014）17-0161-03 　　Investigation of relationship between salt-sensitivity and blood pressure Lantian Yao population in Huizhou city 　　【Abstract】Objective To study the difference of salt-sensitivity (SS) and its effect on alteration of blood pressure and renal injury in Lantian Yao population. Methods This study was performed in 1030 Yao residents who were determined by unified standard and compared with 1280 Han residents. All the participants carried out two stages of dietary intervention including low salt diet (salt 3g/d x 7d) and following high salt diet (salt 18g/d x 7d). Daily blood pressure was measured, while blood and urine beta;2-MG, urine Alb, Cr and Alb/Cr were examined. Results The percentage of SS Yao participants was 16.5%, which was lower than Han ones (P lt;0.05). From the diet of low salt to high salt, both of systolic blood pressure and diastolic blood pressure remarkably increased. Meanwhile, in the SS group, two SS indexex of △H-LMABP and △H-BMABP were 6.9plusmn;4.3 mmHg and 6.3plusmn;4.4 mmHg, which were higher than those in salt-resistance (SR) group representing as 0.4plusmn;4.2 mmHg and 1.0plusmn;3.7 mmHg, respectively (P lt;0.01). In addition, a rise in urine beta;2-MG and Alb/Cr was observed in SS Yao group compared with SR group