慢性肾炎采用缬沙坦联合阿托伐他汀钙治疗的效果观察.docVIP

精品论文 参考文献 慢性肾炎采用缬沙坦联合阿托伐他汀钙治疗的效果观察 常德市第一人民医院老年病科 湖南常德 415000 【摘 要】目的：分析慢性肾炎采用缬沙坦联合阿托伐他汀钙治疗的效果。方法：选取106例慢性肾炎患者作为研究对象，随机进行分组；对照组53例，采取缬沙坦治疗；观察组53例，在对照组治疗的基础上，采取阿托伐他汀钙治疗；对比两组患者治疗前后血尿素氮（BUN）、血清肌酐（Scr）、超敏C-反应蛋白（hs-CRP）、尿蛋白（PRO）、肾小球滤过率（GFR）水平，综合评价患者的治疗效果，并作对比分析。结果：治疗后，两组患者BUN、Scr、hs-CRP、PRO水平均较治疗前明显降低，GFR水平较治疗前明显升高，差异具有统计学意义（P＜0.05），但观察组患者BUN、Scr、hs-CRP、PRO、GFR水平改善程度大于对照组，差异具有统计学意义（P＜0.05）；观察组临床总有效率为90.57%，大于对照组的77.36%，经chi;2检验，差异具有统计学意义（P＜0.05）。结论：缬沙坦联合阿托伐他汀钙可协同提高慢性肾炎的治疗效果，对于控制病情、改善肾功能及预后均具有积极作用。 【关键词】慢性肾炎；缬沙坦；阿托伐他汀钙 Chronic nephritis using valsartan combined atorvastatin calcium therapy Effect FuCishuang Changde City First Peoples Hospital of Geriatrics，Changde，Hunan 415000 [Abstract] Objective：To analyze the effect of chronic nephritis using valsartan combined atorvastatin calcium therapy. Methods：106 cases of chronic nephritis patients as research subjects were randomly grouped；53 cases in the control group taking valsartan treatment；53 cases of observation group，on the basis of the control group taking atorvastatin calcium therapy；two comparison patients before and after treatment of blood urea nitrogen（BUN），serum creatinine（Scr），high-sensitivity C- reactive protein（hs-CRP），urinary protein（PRO），glomerular filtration rate（GFR）level，comprehensive evaluation of patients treatment，and for comparative analysis. Results：After treatment，patients were BUN，Scr，hs-CRP，PRO level significantly lower than before treatment，significantly higher GFR levels than before treatment，the difference was statistically significant（Plt;0.05），but the observation group were BUN，Scr，hs-CRP，PRO，GFR level the degree of improvement than the control group，the difference was statistically significant（Plt;0.05）；the observation group total effective rate was 90.57%，77.36% higher than the control group，the chi;2 test，the difference statistically significant（Plt;0.05）. Conclusion：Valsartan combined with atorvastatin calcium synergistically enhance the therapeutic effect of chr