Relationships among androgen receptor CAG repeat polymorphism, sex hormones and penile length in Han adult men from China: a cross-sectional study.pdfVIP

Relationships among androgen receptor CAG repeat polymorphism, sex hormones and penile length in Han adult men from China: a cross-sectional study.pdf

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AsianJournalofAndrology(2014)16。47 _481 @ 2014AJA.SIMM &SJTU Allrightsreserved 1008—682X 一薹 善 墨 wwwasiaandrocorn;wwwajandrology.com OpenAccess ORIGINALARTICLE RelationshipsamongandrogenreceptorCAG repeat polymorphism,sexhormonesandpenilelengthin Hanadultmenfr0m China:across—sectionalstudy Yah—MinMa,,,Kai-JieWu,,LiangNing,JinZeng,BoKou,,Hong—JunXie,,Zhen—KunMa,, Xin—YangWang,Yong—GuangGong,Da—LinHe Thisstudyaimedtoinvestigatethecorrelationsamongandrogenreceptor(AR)CAGrepeatpolymorphism。sexhormonesandpenile IengIhinhealthyChineseyoungadultmen.TwohundredandfifIy.threehealthymen(aged22.8±3.1years)wereenrolled.The individualsweregroupedasCAGshort(CAG。)iftheyharboredrepeatIengthof20orasCAGlong(CAG.)iftheirCAGrepeatlength was20.Bodyheightw/eight,penileIengthandotherparameterswereexaminedandrecordedbythespecifiedphysicians;CAG repeatpolymorphism wasdeterminedbythepolymerasechainreaction(PeR)method;andtheserum Ievelsofthesexhormones weredetectedbyradioimmunoassay,Student’st-testorlinearregressionanalysiswasusedtoassesstheassociationsamong ARCAGrepeatpolymorphism。sexhormonesandpenileIength.Thisinvestigationshowedthattheserum totaItestosterone(T) leve1waspositivelyassociatedwiththeARCAG repeatIength(P=0.01):whereas。nosignificantcorrelationofTorARCAG repeatpolymorphism withthepenileIenmhwasfound (P=0.593).Interestingly,aninverseassociationwasobservedbetween serum prolactin(PRL)Ievelsandpenilelengthbylinearregressionanalyses(13=一0.024。P=0.039。95%confidenceintervaI (C1):一0.047。0).Collectively,thisstudyprovidesthefirstevidencethatserum PRL.butnotTorARCAG repeatpolymorphism。 iscorrelatedwithpenilelengthintheHanadultpopulationfrclm nOrthwesternChina. AsianJournalofAndrology(2014)16.478-481:doi:10.4103/1008—682X.124560;pubIishedonliBe:28February2014 Keywords:androgenreceptor;CAG repeat;testosterone;prolactin;penilelength lNTR0DUCT10N

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