雌激素对失血性休克孕兔肾功能的影响.PDFVIP

·232 · doi 10.3969/j.issn. 1673-4254.2014.02.18 J South Med Univ, 2014, 34(2): 232-235 基础研究 雌激素对失血性休克孕兔肾功能的影响雌激素对失血性休克孕兔肾功能的影响 刘士三，龚时鹏，吴 焕，杨 翠，刘倩倩，黄启涛，余艳红 南方医科大学南方医院妇产科，广东 广州 510515 摘要：目的探讨雌激素对失血性休克孕兔肾功能的影响。方法 将40 只妊娠新西兰白兔随机分为4 组，正常对照组（NG ），麻醉 后不做放血及复苏处理；雌激素对照组（E G），实验60 min 静脉注射雌激素，余同NG 组；雌激素休克组（E SG）、果糖休克组 2 2 （FSG），两组均在实验0~ 15 min 做放血处理，孕兔达休克血压40 mmHg 后维持45 min ，然后分别静脉注射雌激素及果糖，观察 20 min 后予以复苏。对比各组不同时间点血清尿素氮、肌酐浓度变化，观察孕兔肾脏病理结果。结果 NG 组和E2G 组血清尿素 氮及肌酐水平在实验过程中无明显变化；失血性休克后，FSG 组及E2 SG组血清尿素氮水平均在实验80 min 始持续升高，FSG 组 血清尿素氮水平明显高于E SG组（P0.05）；FSG 组及E SG组血清肌酐水平在实验开始持续升高，60 min 始持续下降，E SG组 2 2 2 下降速率快于FSG 组（P0.05）。结论 雌激素能有效降低失血性休克孕兔血清尿素氮、肌酐水平，减轻肾脏病理损害，对失血性 休克孕兔的肾功能有一定的保护作用。 关键词：雌激素；失血性休克；尿素氮；肌酐；孕兔 Effects of estrogen on renal function of pregnant rabbits with hemorrhagic shock LIU Shisan, GONG Shipeng, WU Huan, YANG Cui, LIU Qianqian, HUANG Qitao, YU Yanhong Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Abstract: Objective To evaluate the effects of estrogen on renal function of pregnant rabbits with hemorrhagic shock. Methods Forty pregnant New Zealand white rabbits were randomized into 4 groups, namely normal control group (NG group, with anesthesia only), estrogen group (E group, with additional estrogen injection at 60 min), estrogen-hemorrhagic shock (E SG) 2 2 group and fructose-hemorrhagic shock (FSG) group. In the latter two groups, the rabbits were subjected to phlebotomy for 15 min to induce hemorrhagic shock with a blood pressure of 40 mmHg; after maintenance of the pressure for 45