中药内服配合膝关节腔注射治疗膝骨性关节炎的临床研究Clinical study on the treatment of knee osteoarthritis with traditional Chinese medicine and injection of the knee joint cavity.pdfVIP

提 要 目的：通过观察中药内服配合得宝松与施沛特膝关节腔注射的方法对于膝骨关节 炎临床症状、体征的改善情况，观察中药汤剂配合膝关节腔注射治疗膝骨关节炎（肝 肾不足，筋脉瘀滞型）的临床效果，探讨此方法防治膝骨关节炎的机理，进一步为膝 骨关节炎的治疗提供新的有效方法。方法：临床选择 60 例膝骨关节炎患者，全部病 例均来自 2010 年 9 月至 2011 年 11 月山东中医药大学第二附属医院骨科门诊。按随 机分组原则将60例患者分为治疗组和对照组，两组每组各30名。治疗组采用中药汤 剂内服,配合得宝松与施沛特膝关节腔注射（前两周单独注射得宝松，后五周单独注 射施沛特）。对照组只采用得宝松与施沛特膝关节腔注射（前两周单独注射得宝松， 后五周单独注射施沛特）。治疗后观察临床疗效，并用SPSS统计软件进行分析。结果： 1.两组病例治疗前后比较P＜O．01,说明两种治疗方法对膝关节骨性关节炎（肝肾不 足，筋脉瘀滞型）都有较好的疗效。2两组病例治疗结束时症状体征评分治疗组与对 照组比较有差异（P＜O．05﹚，说明治疗组的治疗方法优于对照组。3.治疗结束 5 个月后治疗组与对照组症状、体征积分及疗效相比有显著差异（P＜0．01﹚，说明治 疗组治疗膝骨关节炎的远期临床疗效显著，较对照组能更长时间的改善和消除 KOA 临床症状和关节炎症，改善和促进关节功能恢复，提高患者生活质量，值得进一步研 究和推广。 关键词 膝关节腔注射；膝骨关节炎；中药；玻璃酸钠；得宝松 Chinese Herbs with the clinical study of the knee joint cavity injection treatment for knee arthritis Specialty: Orthopedics of TCM Author: Liu Gang Tutor: Dong Jianwen Abstract Objective: To observe the effect of oral administration with the Diprospan and Sodium Hyaluronate Injection knee cavity injection method for the improvement of clinical symptoms of knee osteoarthritis, signs, and observe the effect of decoction with the clinical effect of the treatment of knee osteoarthritis in the knee joint cavity injection explore the mechanism of this method of prevention and treatment of knee osteoarthritis, further to provide a new and effective method for the treatment of osteoarthritis of the knee. Methods: The clinical selection of the 60 cases of knee osteoarthritis patients, all patients from the orthopedic clinic of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine in September 2010 to November 2011. 60 patients were randomly divided into treatment group