非甾体类抗炎药与胃肠道细胞凋亡研究.pdfVIP

非甾体类抗炎药与胃肠道细胞凋亡 张 峰综述 雷秀玲审校 昆明医学院药理教研室 昆明 650031 中图分类号 R735 文献标识码 A 文章编号 摘要 非甾体类抗炎药 Non-steroidal anti- inflammatory drugs, NSAIDs 是一类使用很广泛的处方药 主要用于关节炎的治疗 长期服用非甾体类抗炎药可引起胃 十二指肠溃疡 而在结肠可使肿瘤消退 近年来的研究认为 非甾体类抗炎药除了抑制环加氧酶活性外 还干扰葡萄糖的能量代谢 磷酸戊糖 途径的两支路和经由糖酵解及氧化磷酸化的能量生成 对磷酸戊糖途径的影响可能是非甾体类抗炎 药发挥不同作用的关键 本文综述了非甾体类抗炎药在诱导胃肠道细胞凋亡机制方面的研究进展 关键词 非甾体类抗炎药 胃肠道细胞 细胞凋亡 磷酸戊糖途径 Progress in NSAIDs-induced apoptosis in the gastrointestinal tract ZHANG Feng LEI Xiuling (Department of Pharmacology,Kunming medical college,Kunming 650031,China) [Abstract] Non-steroidal anti- inflammatory drugs(NSAIDs) are among the most widely prescribed drugs primarily for treatment of arthritis. NSAIDs can have two effects independent of their anti- inflammatory actions. In the stomach and small bowel long term NSAIDs consumption can lead to peptic ulceration. Whereas in the colon NSAIDs usage can regress existing tumours. In addition to inhibiting cyclooxygenase(COX) activity, recent study has shown that NSAIDs can also interfere with glucose metabolism through both arms of the pentose phosphate pathways and energy production via glycolysis and oxidative phosphorylation. The influence to the pentose phosphate pathways is likely critical to cause different actions of NSAIDs. This review outlined progress in NSAIDs-induced apoptosis in the gastrointestinal tract. [Key word] Non-steroidal anti- inflammatory drugs(NSAIDs); gastrointestinal cells; apoptosis; the pentose phosphate pathway 1. 引言 非甾体类抗炎药包括了许多结构各异的化合物 其抗炎作用及造成不良反应的严重程度也不相 同 最先合成的非甾体类抗炎药是乙酰水杨酸 即阿司匹林 该药有广泛的解热 镇痛和抗炎作用 随后 陆续开发出几种不同类型的非甾体类抗炎药 主要有 丙酸类 包括萘普生 naproxen 和布 洛芬 ibuprofen