概率分布模拟在肺癌患者化疗输液安排中的应用.docVIP

精品论文 参考文献 概率分布模拟在肺癌患者化疗输液安排中的应用 刘清霞 曾小燕 周冬莲 刘庆相 　　 [摘 要]目的 合理安排肺癌患者化疗输液，缩短化疗药物配置后至输液期间的滞留时间，减轻药物的毒副反应。方法 根据肺癌患者的输液量、输液时间、药物性能、药物作用时间不同，建立概率模拟，按模拟程序安排肺癌患者化疗输液，观察和记录化疗药物配置后至输液期间的滞留时间、输液速度、输液时间，并记录患者输液后的毒副反应情况，然后与传统的化疗输液方法进行比较。结果　按模拟程序执行化疗输液与传统方法化疗输液，在化疗药物配置后至输液期间的滞留时间有非常显著差异（P＜0.01）；患者输液后发生消化道反应、全身反应、过敏反应等毒副反应也有显著差异（P＜0.05）。结论 利用概率分布模拟，能够根据患者的输液量、药物性能、药效时间，合理安排化疗输液工作，能缩短化疗药物配置后至输液期间的滞留时间；减少发生消化道反应、全身反应、过敏反应等毒副反应的发生。 　　[关键词] 概率分布 化疗输液 模拟 　　DOI:10.3760/cma.j.issn.1672-7088.2014.21.9 　　作者单位：33002，江西南昌市，江西省肿瘤医院 　　[作者简介]刘庆相 ，通信作者； 　　刘清霞，女，大专，副主任护师。 　　The Application of Probability Distribution Simulation in Chemotherapy Infusion among Lung Cancer Patients 　　Liu Qingxia, Zeng Xiaoyan, Zhou Donglian,, Liu Qingxiang, 　　Abstract: Objective To arrange the chemotherapy infusion of lung cancer patients, shorten the residence time of drug allocation to transfusion period and reduce the toxicity of drugs. Methods The probability simulation was established according to the amount of transfusion, transfusion time, function of drugs and the action time of drugs. The chemotherapy infusion was conducted according to the simulation program, and the residence time from the chemotherapy drug allocation to transfusion, transfusion speed, transfusion time and adverse reaction of patients after infusion were recorded and compared with the traditional method of chemotherapy infusion. Results Comparing with the traditional method of chemotherapy infusion, the retention time from chemotherapy drug allocation to infusion according to the simulation program was of significant difference (P lt; 0.01); toxicity, gastrointestinal reaction, systemic reaction and allergic reactions after infusion also had remarkable difference (P lt; 0.05). Conclusion By using the probability distribution model, the chemotherapy transfusion can be reasonable arranged according to patientsrsquo; amount of infusion, the function of drugs and action time of drugs, and the retention time from chemotherapy d