瑞舒伐他汀治疗急性脑梗死临床疗效观察.docVIP

精品论文 参考文献 瑞舒伐他汀治疗急性脑梗死临床疗效观察 李巧转　季波 江苏省泰兴市人民医院神经内科　江苏　泰兴　２２５４００ 作者简介:李巧转,女,(１９８１－),硕士研究生,主治医师,研究方向:急性脑血管病的重症监护. 　　【摘要】　目的　探讨瑞舒伐他汀治疗急性脑梗死的临床疗效.方法　选取泰兴市人民医院神经内科２０１４－０６至２０１５－０３收治的急性脑梗死患者８４例为研究对象,随机分为治疗组和对照组.治疗组４２例,在常规治疗的基础上给予瑞舒伐他汀钙片治疗;对照组４２例,给予常规治疗,包括抗血小板、管理血压血糖、神经营养等,连续治疗３个月.记录比较两组患者治疗前、后血清超敏C‐反应蛋白(hs‐ CRP)和脂蛋白相关磷脂酶A２(Lp－PLA２)水平变化,并对患者进行神经功能缺损程度评分,评价疗效.结果　两组治疗后血清Hs－CRP 和Lp－PLA２均有明显降低,并且治疗组二者降低更明显(P ＜０??０５);治疗组NHISS评分显著低于对照组(P ＜０??０５);治疗组总有效率显著高于对照组(P ＜０??０５).结论　瑞伐他汀治疗急性脑梗死能够显著降低患者的NHISS 评分, 疗效显著. 【关键词】　瑞舒伐他汀;急性脑梗死;超敏C‐反应蛋白;脂蛋白相关磷脂酶A２CurativeEffectObservationofRosuvastatinintheTreatmentofAcuteCerebralInfarctionJibo,Liqiao－zhuan,DepartmentofNeurology,TaixingPeoplersquo; sHospital,Jiangsu２２５４００,China【Abstract】:ObjectiveToexploretheclinicaleffectofrosuvastatininpatientswithacutecerebralinfarction??Methods:８４patientswithacutecerebralinfarcＧtion,whoweretreatedinTaixingPeoplersquo;sHospitalduringJune２０１４toMarch２０１５,wererandomlydividedintotreatmentgroupandcontrolgroup??Treatmentgroup,４２cases,wasgivenrosuvastatinonthebasisofconventionaltreatment??Thecontrolgroupwastreatedwithconventionaltherapyforthreemonths,incluＧdingplateletaggregation,controllingbloodsugarandbloodpressureandprotectingbraincells??Thebeforeandaftertreatmentstatusof２groupsofpatientswasrecordedandcomparedonthelevelsandchangesofserumhighsensitivityC‐reactiveprotein(hs‐ CRP)andlipoprotein－associatedphospholipaseA２(Lp－PLA２)?? Meanwhile,patientsrsquo;neurologicaldeficitwerescoredandevaluated??Results:Thehs－CRPandLp－PLA２inserumofpatientsfrombothgroupswereapparentlydecreasedaftertreatment,andthetreatmentgrouphadmoresignificantdeclineonbothdata(P＜０??０５)??Aftertreatment,theNHISSscoreinthetreatＧmentgroupwasgreatlylowerthanthatofthecontrolgroup(P＜０??０５),thetotalefficiencyinthetreatmentgroupwasobviouslyhigherthanthatofthecontrolgroup【(KPey＜w０??or０d５s)】Conclusion??:RousvastatintreatmentofacutecerebralinfarctionpatientscaneffectivelydecreasetheNIHSSscore?? rosuvastatin;acutecerebralinfarction;highsensitivityC‐reactiveprot