短暂性脑缺血发作患者血液炎性因子的测定及其临床意义.docVIP

精品论文 参考文献 短暂性脑缺血发作患者血液炎性因子的测定及其临床意义 解新荣 郝茹（兰州军区乌鲁木齐总医院老年病科 830000） 【摘要】目的 探讨血中炎性因子与短暂性脑缺血发作（transient ischemic attack,TIA）的相关性及其临床意义。方法 对43例TIA患者和39例对照外周血中C反应蛋白（CRP）、D-二聚体(D-dimer，D-d)、血清基质金属蛋白酶-9（matrix metalloproteinase-9，MMP-9）、基质金属蛋白酶组织抑制因子-1(tissue-inhibitor of metalloproteinase-1, TIMP-1)水平进行检测，并进行多因素Logistic回归分析。结果 与TIA相关的单因素分析显示TIA患者血CRP、D-d、MMP-9和TIMP-1水平高于对照组，两组比较具有显著性差异；多因素Logistic回归分析提示：TIMP-1与是否患病关系最密切。结论 血中炎性因子在TIA后都有不同程度升高，它们参与了TIA的病理生理过程，与TIA密切相关。 【关键词】 短暂性脑缺血发作 C反应蛋白 D-二聚体 基质金属蛋白酶-9 基质金属蛋白酶组织抑制因子-1 【中图分类号】R743 【文献标识码】A 【文章编号】2095-1752（2013）29-0124-02 Study on the relationship between transient ischemic attack and inflammatory factors in blood and its clinical significance Xie Xin-rong, Hao Ru. Department of Geriatrics,Urumqi General Hospital of Lanzhou Command, PLA, Urumqi 830000, China 【Abstract】 Objective To evaluate the association of C-reactiveprotein(CRP), D-dimer(D-d), matrix metalloproteinase-9(MMP-9) and tissue-inhibitor of metalloproteinase-1(TIMP-1) in blood and transient ischemic attack(TIA) and its clinical significance. Methods Blood levels of CRP, D-d, MMP-9 and TIMP-1 were respectively measured and selected for Logistic regression analysis in 43 TIA patients and 39 controls. Results CRP, D-d, MMP-9 and TIMP-1 levels in blood were significantly elevated in TIA patients, comparing with control group(P〈0.05). Data from logistic regression analysis indicated that TIMP-1 were most closely related to whether suffering from TIA. Conclusion Part of inflammatory factors in blood were elevated after TIA, they may be involved in the pathophysiological process of TIA and are closely related with TIA. 【Key words】 transient ischemic attack C-reactiveprotein D-dimer matrix metalloproteinase-9 tissue-inhibitor of metalloproteinase-1 有研究发现，动脉粥样硬化为短暂性脑缺血发作（transient ischemic attack,TIA）最常见的原因[1]，动脉粥样硬化的不稳定斑块，也称易损斑块，因其质地松散易于破裂，更易发生TIA或缺血性卒中，而炎症反应是斑块破裂及不稳定的主要原因。一些炎性因子在发病早期即可在外周血中被检测到，其水平有助于