周期，准周期和混沌的复杂钙振荡之间的转换研究.pdfVIP

张凤等 No.: 周期，准周期和混沌的复杂钙振荡之间的转换◆ ★ , 张凤 陆启韶 北京航空航天大学理论力学教研室，北京 100191 摘要 基于钙诱导的钙释放原理系统研究一个数学模型的细胞内的复杂的钙振荡。考虑钙离子诱导IP3 降解。在比较大的 参数范围内，周期，准周期和混沌的复杂钙振荡存在。并在一定范围内交替出现。通过ISI 和李亚普诺夫指数也观察到 了它们的存在。结果表明兴奋剂诱导IP3 降解可能是复杂钙振荡出现的原因。 关键词 周期，混沌，钙振荡 Transition in the Periodic , quasi-Periodic and chaotic calcium oscillations Zhang feng, Lu qishao 1Division of Theoretical Mechanics, Beihang University, Beijing, 100191, China Abstract Complex intracellular Ca2+ oscillations are systematically investigated in a mathematical model based on the mechanism of Ca2+-induced Ca2+ release (CICR), taking account of the Ca2+-stimulated degradation of inositol 1, 4, 5-trisphosphate (IP3) by a 3-kinase. Periodic, quasi-periodic and chaotic bursting oscillations exist in a wide range of parameter values and occur alternatively as the parameters change slightly. The transition among them can be observed by the evidence in their interspike interval and the Lyapunov exponent. These results reveal the role of agonist-stimulated of IP3 degradation as a possible source for complex patterns in Ca2+ signaling. The analysis of bursting can be carried out by studying the solution structure. Key words Period, Chaos, Calcium oscillation 1引言 近年来，在一些细胞中（特别是肝细胞），产生类 受到细胞外兴奋剂刺激时，例如改变荷尔蒙或神 似簇的复杂的钙振荡行为，实验中许多电兴奋细胞接 经传递素[1],[2] [3] 受到特殊兴奋剂的刺激[9] ，大量细胞都有钙振荡。在某些细胞中 ， ，会有类似的现象。为了揭示 只有改变胞液或钙存储中钙的浓度才可以产生钙振 这些复杂的钙振荡，一些理论模型已经被提出 ，这其 荡，它对肌体的某些功