福辛普利与缬沙坦对缺血性心肌病血尿酸和心功能的对比研究.docVIP

精品论文 参考文献 福辛普利与缬沙坦对缺血性心肌病血尿酸和心功能的对比研究 1大庆市人民医院 163316；2大庆龙南医院 163453 摘要：目的 浅析并讨论福辛普利与缬沙坦对缺血性心肌病血尿酸（UA）和心功能的对比影响。方法 此次研究的对象是选择78例缺血性心肌病患者。将其临床资料进行回顾性分析，并随机分为A组和B组，每组39例。A组采用福辛普利片进行治疗，B组给予缬沙坦胶囊治疗。比较两组患者UA与心功能改善情况。结果 治疗结果显示，A、B组患者治疗后的心功能改善情况均优于治疗前（Plt;0.05），A组与B组心功能改善效果组间比较差异无统计学意义（Pgt;0.05）；B组患者治疗前后的UA含量比较差异具有统计学意义（Plt;0.05）；A组患者治疗前后的UA含量比较差异无统计学意义（Pgt;0.05）。结论 在治疗缺血性心肌病时，福辛普利与缬沙坦对改善患者心功能情况并无差异，而缬沙坦可以有效降低患者UA水平。 关键词：福辛普利；缬沙坦；缺血性心肌病 [Abstract] Objective To analyze and discuss the effects of Phu Simpson Leigh and valsartan on serum uric acid（UA）and cardiac function in patients with ischemic cardiomyopathy. Methods the study subjects were selected in 78 patients with ischemic cardiomyopathy. The clinical data were retrospectively analyzed，and were randomly divided into A group and B group，with 39 cases in each group. Group A was treated with fosinopril treatment，B group received the treatment of Valsartan Capsules. UA and cardiac function improvement were compared between the two groups. Result the curative effect shows，group A and group B after treatment in patients with cardiac function improvement were better than before treatment（P lt; 0.05）and cardiac function in group A and group B improved effect between group difference no statistical significance（P gt; 0.05）；B group before and after treatment in patients with UA content difference was statistically significant（P lt; 0.05）；a group before and after treatment in patients with UA content difference no statistical significance（P gt; 0.05）. Conclusion in the treatment of ischemic cardiomyopathy，Phu Simpson Leigh and valsartan have no difference in improving the cardiac function of the patients，and valsartan can effectively reduce the level of UA. [Key words] Phu Simpson Leigh；valsartan；ischemic cardiomyopathy 临床实践表明，由不同原因引起的心力衰竭在使用血管紧张素转换酶抑制剂（ACEI）与血管紧张素受体Ⅰ（ATⅠ）拮抗剂时，临床效果已经被认同[1]。缺血性心肌病在发生心力衰竭时，部分炎症介质会出现明显升高的情况，如UA水平。事实上，UA水平在一定程度上就已经表明心力衰竭的严重性。本文将本院收治的缺血性心肌病患者78例作为研究对象，研究探讨福辛普利与缬沙坦对缺血性心肌病UA和心功能的影响，现报告如下