米氮平改善消化道肿瘤恶液质食欲和营养状况的初步研究.docVIP

精品论文 参考文献 米氮平改善消化道肿瘤恶液质食欲和营养状况的初步研究 　　谢飚 贾林 平丽 吴琼 　　（广州医学院附属广州市第一人民医院消化内科 广东广州 510180） 　　【摘要】目的：观察米氮平改善消化道肿瘤恶液质患者食欲和营养状态的疗效及可能机制。方法：82例消化道肿瘤恶液质患者，随机分为治疗组（n=52），对照组（n=30），治疗组给予米氮平口服1月，对照组给予安慰剂。观察两组食欲、体重、Karnofsky评分、BMI、TSF、MAC及血浆瘦素水平在治疗前后的变化。结果：米氮平组患者治疗后食欲改善，体重增加，Karnofsky评分增加，BMI、TSF、MAC及血浆瘦素升高，和对照组比较有显著性差异（plt;0.05）。结论：米氮平改善消化道肿瘤恶液质患者的食欲及营养状态有较好疗效，瘦素可能参与了其作用过程。 　　【关键词】 米氮平 消化道肿瘤相关恶液质 食欲 营养状态 瘦素 　　【中图分类号】R459.3 【文献标识码】A 【文章编号】2095-1752（2013）36-0041-02 　　Preliminary study of the effect of Mirtazapine in improving appetite and nutritional status in patients with digestive cancer related cachexia 　　XIE Biao,JIA Lin,PING Li, Wu Qiong. 　　Department of Gastroenterology, Guangzhou First Municipal Peoples Hospital Affiliated to Guangzhou Medical College, Guangzhou,510180,Guangdong Province, China. 　　【Abstract】Objective To observe the effect of mirtazapine in improving the appetite and nutritional status in patients with digestive cancer related cachexia and its mechanism. Methods：82 patients with digestive cancer related cachexia were divided into two groups: the treatment group(n=52) was treat with Mirtazapine and the control group(n=30) was treat with placbo. The appetite,body weight, Karnofsky score, BMI, TSF, MAC and level of serum leptin in two groups were compared. Results:The appetite, body weight and Karnofsky score were obviously improved after Mirtazapine treatment in the treatment groups patients; The level of BMI、TSF、MAC and serum leptin were increased in same groups. The difference between two groups was significant（Plt;0.05）. Conclusion: Mirtazapine can improve the appetite and nutritional status in patients with digestive cancer related cachexia.Leptin maybe involved in the process. 　　【Key words】Mirtazapine Digestive cancer relatd cachexia Appetite Nutritional status Leptin 　　肿瘤恶液质（cancer cachexia）是指以厌食、早饱、进行性虚弱、体重下降和营养不良为特征的衰竭综合征。消化道肿瘤相关恶液质尤为常见，与80%的患者死亡直接相关，为独立的负性预后评估因素，成为临床医生不可回避的医