结核性胸膜炎患者胸腔积液T淋巴细胞亚群动态变化的临床意义.docVIP

精品论文 参考文献 结核性胸膜炎患者胸腔积液T淋巴细胞亚群动态变化的临床意义 1，青岛市胸科医院 胸二科 266043 2，青岛疗养院 体检中心 266000 摘要：目的 探究结核性胸膜炎患者胸腔积液T淋巴细胞亚群动态变化的临床意义。方法 随机选取2015年4月~2016年6月来我院就诊并且已经确诊为渗出性的结核性胸膜炎患者50例作为观察组，另选取50例正常患者作为对照组。 对比观察组和对照组患者中的外周静脉血以及胸液中的T细胞亚群改变差异。结果 观察组患者的CD3＋、CD8＋T细胞数量显著性高于对照组（Plt;0.05），CD4＋T细胞观察组和对照组无显著性差异（Pgt;0.05），CD4＋/CD8＋的比例则对照组显著性高于观察组（Plt;0.05）。化学治疗后，观察组的CD8＋T细胞显著性降低（Plt;0.05）；CD4＋/CD8＋比例显著性升高（Plt;0.05）；CD3＋、CD4＋则无显著性差异（Pgt;0.05）。结论 对患者的静脉血以及胸水中的淋巴细胞亚群可以加强对结核性胸膜炎的鉴别，化学治疗后，对患者的细胞免疫抑制状态可以有着显著性改善。 关键词：结核性胸膜炎；胸腔积液；T淋巴细胞；临床意义 【中图分类号】R181.3+2【文献标识码】A【文章编号】1001-5213(2016)08-0300-01 Abstract: objective to explore the tuberculous pleurisy patients with pleural effusion of the dynamic variation of the T lymphocyte subgroup clinical significance. Methods randomly selected in April 2015 ~ June 2016 to our hospital and it has been diagnosed with 50 cases of exudative tuberculous pleurisy patients as observation group, the other selected 50 cases of normal patients as control group. Contrast observation group and control group in patients with peripheral venous blood and thoracic fluid changes in T cell subgroup differences. Results observation group number of CD3 + and CD8 + T cells in patients with significantly higher than that of control group (P lt; 0.05), CD4 + T cells in observation group and control group no significant difference (P gt; 0.05), the proportion of CD4 + / CD8 +, the control group significantly higher than in observation group (P lt; 0.05). After chemical treatment, the observation group of CD8 + T cells were significantly lower (P lt; 0.05); CD4 + / CD8 + ratio significantly higher (P lt; 0.05); CD3 +, CD4 +, no significant difference (P gt; 0.05). Conclusion for patients with venous blood and lymphocyte subsets of chest water can strengthen the identification of tuberculous pleurisy, chemical treatment, cells of the patients with immunosuppressive state can have a significant improvement. Key words: tuberculous pleurisy; Pleural effusion. T lymphocyte; Clinical signi