结膜瓣遮盖联合睑裂缝合术予规范化药物干预治疗难治性角膜溃疡的临床分析.docVIP

精品论文 参考文献 结膜瓣遮盖联合睑裂缝合术予规范化药物干预治疗难治性角膜溃疡的临床分析 陈莺 　　（四川省仁寿县人民医院 四川 仁寿 620500） 　　【摘 要】目的：分析结膜瓣遮盖联合睑裂缝合术予规范化药物干预治疗难治性角膜溃疡的临床疗效。方法：将我院收治的54例（54只眼）难治性角膜溃疡患者随机分为观察组27和对照组27例。对照组患者行结膜瓣遮盖联合睑裂缝合术予常规药物干预治疗，观察组患者行结膜瓣遮盖联合睑裂缝合术予规范化药物干预治疗。评价2组患者的临床治疗效果，检测手术前后患者的裸眼视力及泪膜功能，并随访统计患者的复发率。结果：观察组患者临床治疗的总有效率为92.59%，对照组为74.07%，2组比较，差异具有统计学意义（P＜0.05）。术后1个月、3个月，2组患者的裸眼视力、BUT及STt较术前均提高，但观察组患者的提高幅度均大于对照组（P均＜0.05）。1年的随访期间，观察组患者角膜溃疡的复发率为7.41%，对照组为22.22%，2组比较，差异具有统计学意义（P＜0.05）。结论：在结膜瓣遮盖联合睑裂缝合术治疗难治性角膜溃疡的基础上配合规范化药物干预能有效提高手术治疗效果，促进裸眼视力及泪膜功能的提高，并降低复发率。 　　【关键词】难治性角膜溃疡；结膜瓣遮盖；睑裂缝合术；药物干预 　　【中图分类号】R772.21 【文献标识码】B 【文章编号】1003-5028（2015）7-0152-02 　　Analysis of conjunctival flap covering joint palpebral fissure surgery and standardization of drug intervention in the treatment of refractory corneal ulcer 　　【Abstract】objective: to analyze conjunctival flap covering joint palpebral fissure surgery and standardization of the clinical curative effect of drug intervention in treatment of refractory corneal ulcer. Methods: our hospitalrsquo;s 54 cases (54 eyes) with refractory corneal ulcer patients were divided into observation group (27) and the control group (27 cases). The control group patients were treated byjoint palpebral fissures and conjunctival flap covering surgery and conventional drug intervention, the observation group of patients were treated byconjunctival flap covering joint palpebral fissure surgery and standardization of drug intervention. 2 groups of patients with the clinical treatment effect were assessed, before surgery and after surgery, patients with the naked eye eyesight and appear function was detected; the recurrence rate of the patients was counted. Results: observation group of patients with clinical treatment the total effective rate was 92.59%, control group was 74.07%, the comparison of two groups, statistically significant difference (P lt; 0.05). After 1 month, 3 months, two group of patients with the naked eye eyesight, BUT and STt before operation were improved, BUT