毒理学相关资料,第三章内容参考文献7.pdfVIP

0090-9556/99/2712-1423–1428$02.00/0 DRUG METABOLISM AND DISPOSITION Vol. 27, No. 12 Copyright © 1999 by The American Society for Pharmacology and Experimental Therapeutics Printed in U.S.A. EFFECT OF SELECTIVE PHASE II ENZYME INDUCERS ON GLUCURONIDATION OF BENOXAPROFEN IN RATS JENNIFER Q. DONG,1 AMY S. ETHERIDGE,2 AND PHILIP C. SMITH1 Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Received April 26, 1999; accepted August 19, 1999) This paper is available online at ABSTRACT: The induction of benoxaprofen (BNX) glucuronidation in rats by KM and Vmax. There appeared to be a trend of increase of the Vmax intragastric administration of three nitrogen heterocycles (quino- of BNX glucuronidation in rat liver microsomes by all three nitrogen line, 2,2-dipyridyl, or 1,7-phenanthroline at 75 mg/kg daily for 3 heterocycles; however, the induction was only significant with days) has been investigated. BNX was administered i.v. at a dose of 1,7-phenanthroline. KM was not noticeably altered by any of the 20 mg/kg to bile-cannulated rats that had been induced. Blood and three inducers. No change of measured hepatic microsomal cyto- bile were collected over 8 h. Liver tissues were also collected at the chrome P-450 activities in the rat was found. BNX glucuronidation end of the 8-h study and used to examine conjuga